Association of Plasma PTX3 Concentration and Outcomes of STEMI

335 of patients with STEMI treated by primary PCI were assayed for PTX3 measurement by ELISA method. The angiographic and clinical outcomes were evaluated according to the PTX3 concentration.

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Key information

Conditions

STEMI Cardiovascular Diseases Coronary; Ischemic Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Indonesian Cardiovascular Research Center

Jakarta, DKI Jakarta, 11420, Indonesia

About this study

335 of patients with STEMI treated by primary PCI were assayed for PTX3 measurement by ELISA method using human PTX3 kit. Blood was drawn at the emergency department before primary PCI. The angiographic and clinical outcomes were evaluated and analyzed according to the PTX3 concentration. The angiographic outcome were thrombus grade on initial angiogram and final TIMI flow. The clinical outcome were ECG resolution after primary PCI and all-cause death at 30 days. The plasma PTX3 concentration was then compared based on the outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with acute STEMI with symptom onset <12 h undergoing primary PCI

Exclusion criteria

Acute STEMI patients who received fibrinolytic therapy

Treatment and study plan

Plasma PTX3 concentration

Other

Long pentraxin 3, thrombus burden, final TIMI flow, ST segment resolution, STEMI, primary PCI

Other names: PTX3

Primary outcomes

The proportion of thrombus grade 4&5 and final TIMI flow <3

Time frame: Intraprocedure

PTX3 concentration was compared based on the outcome

Sponsors and collaborators

Lead sponsor

Indonesian Cardiovascular Research Center

Other

Registry information

Official study title

Association of Plasma Pentraxin 3 Concentration With Angiographic and Clinical Outcomes in STEMI Treated by Primary Angioplasty

Important dates

Study start: 2018
Primary completion: 2018
Study completion: 2018
First posted: Mar 28, 2019
Registry last updated: Mar 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed