Association of Long-term Conditions With Survival Following Heart Attack in England and Wales

This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.

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Key information

Conditions

Acute Myocardial Infarction Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disease Cerebrovascular Disorders Chronic Disease Chronic Heart Failure Chronic Obstructive Pulmonary Disease Chronic Renal Failure Diabetes Mellitus Disease Attributes Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Glucose Metabolism Disorders Kidney Diseases Kidney Failure, Chronic Lung Diseases Lung Diseases, Obstructive Male Urogenital Diseases Metabolic Diseases Nervous System Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Peripheral Vascular Disease Peripheral Vascular Diseases Pulmonary Disease, Chronic Obstructive Renal Insufficiency Renal Insufficiency, Chronic Respiratory Tract Diseases Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Using observational data from the Myocardial Ischaemia National Audit Project (MINAP) of all hospitalisations for acute myocardial infarction in all acute hospitals in England and Wales, this study aims to determine the extent to which pre-existing long-term conditions are associated with survival following acute myocardial infarction. The study will include an investigation of individual long term conditions for patients with acute myocardial infarction, including chronic heart failure, cerebrovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure or peripheral vascular disease as well as the combination of such conditions and their resulting impact on long term all-cause mortality (up to 8.4 years). In addition, an investigation of the association of receipt of guideline recommended care for acute myocardial infarction patients with pre-existing long term conditions will be made.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients must be 18 years or older

Exclusion criteria

Patients for which mortality data are missing

Treatment and study plan

long term conditions

Other

Long term conditions including diabetes mellitus, chronic obstructive pulmonary disease or asthma, chronic heart failure, chronic renal failure, cerebrovascular disease or peripheral vascular disease.

Primary outcomes

Number of patients who died from any cause by the end of the study censoring period

Time frame: 8.4 years

Death data was obtained from national death records from the Office for National Statistics

Secondary outcomes

Number of patients who received guideline recommended therapy during the study period

Time frame: Any guideline therapy administered during the patients hospital admission for acute myocardial infarction, an average of 4 days

All guideline recommended therapies for acute myocardial infarction relevant to the duration of the study period (2003 to 2013) will be assessed.

Sponsors and collaborators

Lead sponsor

Marlous Hall

Other

Registry information

Official study title

Association of Long-term Conditions With Survival Following Acute Myocardial Infarction in England and Wales

Important dates

Study start: 2003
Primary completion: 2013
Study completion: 2021
First posted: Jan 31, 2017
Registry last updated: May 24, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed