Association of Intestinal Microbiota and the Onset of Perianal Abscess Based on 16S RDNA Amplicon Sequencing

The goal of this observational study is tolearn the association of gut microflora with the onset of perianal abscesses. The main questions it aims to answer are:

Question 1: To understand the structure of rectal microbial community composition and its relationship with pathogenic bacteria in patients with perianal abscess.

Question 2: Understand the structure of rectal microbial community composition in healthy people.

Participants will be collected with rectal secretions and stool specimens.In addition, patients with perianal abscess should also collect pus samples.

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Key information

Conditions

Perianal Abscess

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Xi'an Hospital of Traditional Chinese Medicine

Xi'an, Shaanxi, 710021, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Observation group: ① Age between 18-60 years, local resident of Xi'an; ② met the diagnostic criteria for perianal abscess and underwent surgical treatment in our hospital; ③ did not use antibiotics before treatment; ④ himself and his family members were willing to participate in this study and signed informed consent.

Control group: ① Age between 18-60 years, permanent residents in Xi'an; ② had no serious chronic disease, no abnormality in physical examination in the last 1 week; ③ did not use drugs that may affect intestinal flora in the last one month; ④ himself and his family members are willing to participate in the study and sign the informed consent.

Exclusion criteria

Failing to retain the specimens as required

Treatment and study plan

surgical operation

Procedure

Radical operation for the perianal abscess

Primary outcomes

Observation group: the structure and changes of rectal flora before and after treatment

Time frame: Two months

Analysis of the intestinal microflora based on 16S rDNA amplicon sequencing
Control group: the structure and changes of rectal flora in healthy population

Time frame: Two months

Analysis of the intestinal microflora based on 16S rDNA amplicon sequencing

Sponsors and collaborators

Lead sponsor

Xi'an Hospital of Traditional Chinese Medicine

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: May 17, 2023
Registry last updated: Jan 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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