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NCT Number: NCT07195565

Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients

This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.

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Key information

Conditions

Severe Burns Acute Kidney Injury Burns Critical Illness Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Urogenital Diseases Urologic Diseases Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Dr. Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation

Istanbul, 34865, Turkey (Türkiye)

About this study

Severe burn injury is frequently complicated by acute kidney injury (AKI), which is associated with high morbidity and mortality in intensive care settings. Continuous renal replacement therapy (CRRT) is often required in this patient population; however, the prognostic factors influencing survival remain incompletely defined.

In this retrospective study, we analyzed critically ill burn patients who required CRRT. The primary outcomes were the RIFLE classification at the time of CRRT initiation, the timing of therapy initiation, and patient survival. The secondary outcomes included the presence of comorbidities, the need for mechanical ventilation, inotropic support, and length of hospital stay in non-survivors.

By systematically evaluating these clinical parameters, the study aims to clarify the prognostic impact of CRRT in burn patients and to contribute evidence for optimizing the management of acute kidney injury in this critically ill population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years and older
  • Admitted to and treated in the Burn Intensive Care Unit

Exclusion criteria

  • Patients with an ICU stay of less than 24 hours
  • Patients younger than 18 years
  • Patients with known chronic kidney disease or history of kidney transplantation
  • Patients admitted with toxic epidermal necrolysis (TEN)
  • Patients with estimated glomerular filtration rate (eGFR) ≤ 15 mL/min/1.73m² at admission

Treatment and study plan

Primary outcomes

  1. RIFLE criteria classification at CRRT initiation

    Time frame: Baseline( Day0, at CRRT initiation)

    Patients receiving CRRT will be classified according to the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease) at the time of CRRT initiation. The distribution across categories will be analyzed.

  2. Timing of CRRT initiation

    Time frame: Baseline( Day0, at CRRT initiation, recorded from patient medical records)

    Date and time of initiation of continuous renal replacement therapy (CRRT), obtained from patient medical records.

  3. Survival status of patients

    Time frame: At hospital discharge ( end of hospitalization)

    Survival versus non-survival status at the end of hospitalization.

Secondary outcomes

  1. Presence of comorbidities in non-survivors

    Time frame: Baseline( Day0, at hospital admission)

    Documentation of chronic comorbidities (e.g., diabetes, hypertension, cardiovascular disease) in patients who died after CRRT.

  2. Requirement for mechanical ventilation in non-survivors

    Time frame: Through ICU stay, up to hospital discharge (or death)

    Need for invasive mechanical ventilation among non-survivors receiving CRRT.

  3. Requirement for inotropic support in non-survivors

    Time frame: Through ICU stay, up to hospital discharge or death

    Requirement for vasopressor or inotropic agents among non-survivors receiving CRRT.

  4. Hospital length of stay in non-survivors

    Time frame: From hospital admission through study completion( up to discharge or death)

    Total length of hospitalization measured in days for patients who did not survive after CRRT.

Sponsors and collaborators

Lead sponsor

Pinar Timur Tasci

Other Gov

Registry information

Official study title

The Relationship Between Continuous Renal Replacement Therapy, Mortality, and Hospital Length of Stay in Critically Ill Burn Patients

Acronym: CRRT-BURN

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Sep 26, 2025
Registry last updated
Sep 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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