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OpenTrials
Completed

NCT Number: NCT01840969

Association of Carotid Arterial Circumferential Strain With Left Ventricular Function and Hemodynamic Compromise During Off-pump Coronary Artery Bypass Surgery

This study is aimed to evaluate the association of common carotid artery circumferential strain with the echocardiographic parameters of left ventricular function and the degree of actual hemodynamic deterioration in patients undergoing multi-vessel off-pump coronary artery bypass with preserved left ventricular ejection fraction.

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Key information

Conditions

Three Vessel Coronary Artery Disease

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Yonsei University College of Medicine

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • three vessel coronary artery disease
  • sinus rhythm

Exclusion criteria

  • New York Heart Association functional class ≥3
  • known pulmonary hypertension
  • known valvular heart disease
  • serum creatinine ≥2.0 mg/dL
  • myocardial infarction within 1 week before the surgery
  • history of cerebral or peripheral arterial occlusive disease

Treatment and study plan

Primary outcomes

  1. TTE parameters

    Time frame: 1 day before the surgery

    TTE parameters: left ventricular ejection fraction, left atrial volume index, left ventricular mass, Sm, Em, E/Em

Secondary outcomes

  1. change of intraoperative hemodynamic variables

    Time frame: from after induction of anesthesia, left circumflex artery grafting, and to sternum closure

    TTE parameters: left ventricular ejection fraction, left atrial volume index, left ventricular mass, Sm, Em, E/Em Carotid circumferential strain : Storage of transverse image of the right CCA at approximately 1cm proximal to the bifurcation, manual trace of luminal-intimal border and automatic tracking by frame-to-frame movement of ultrasound reflections (speckles) Hemodynamic variables: cardiac index and mixed venous oxygen saturation obtained from the pulmonary artery catheter and cardiac output monitoring devices

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Apr 26, 2013
Registry last updated
Apr 26, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.