Association of Asprosin in Periodontitis and Acute Coronary Syndrome

Asprosin, a recently discovered glucogenic adipokine, is mainly synthesized by white adipose tissue and released during fasting. Appetite, glucose metabolism, insulin resistance, cell apoptosis, etc. asprosin is associated with diseases such as diabetes, obesity, polycystic ovary syndrome, and cardiovascular diseases. Periodontal tissue may act as a source of endocrine-like inflammatory mediators (such as TNF-α, IL-6 and IL-1) that are important in periodontal inflammation and can affect glucose and lipid metabolism. Production of TNF-α and IL-6 in adipose tissues strengthens the relationship between cardiovascular diseases and periodontitis. Investigators postulated that asprosin may be a candidate for explaining the triangular relationship between cardiovascular and periodontal disease.

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Key information

Conditions

Cardiovascular Diseases Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Atatürk University Faculty of Dentistry

Erzurum, 25240, Turkey (Türkiye)

About this study

Periodontal disease is a chronic, multifactorial, and infectious disease caused by bacteria. It is characterized by the formation of an inflammatory response in the supporting bone and connective tissue against microbial dental plaque, and the nature of the resulting inflammatory response determines the course of periodontal disease. Cardiovascular and periodontal diseases are closely related, presenting a triad association. Asprosin circulates in the blood at nanomolar levels and is taken to the liver, where it activatesinvestigators the G protein-cAMP-PKA pathway, causing rapid glucose release into the circulation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For Healthy group

All individuals were generally healthy,
non-smoking For Myocard Infarctus group
patients with ST elevation of Myocardial Infactus
patient with less than ten teeth

Exclusion criteria

Smokers or those with diabetes or other inflammatory disease
Pregnant or breastfeeding women
None had undergone periodontal therapy and/or antibiotic therapy in the past 6 months.
None has a contagious disease such as HIV or AIDS

Treatment and study plan

Serum samples will be collected. Asprosin levels will be determined by biochemical analysis

Diagnostic Test

Serum samples will be collected from both groups for biochemical analysis.

Primary outcomes

Asprosin Levels

Time frame: two weeks

Determination of asprosin levels by making biochemical analyzes from serum

Sponsors and collaborators

Lead sponsor

Ataturk University

Other

Registry information

Official study title

Serum Asprosin Concentrations in Patients With Periodontitis and Acute Coronary Syndrome

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2023
First posted: Dec 13, 2022
Registry last updated: Jul 20, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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