Association Between Telomere Length and Cardiac Dysfunction

Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.

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Key information

Conditions

Cardiac Toxicity Acute Leukemia Cardiotoxicity Cardiovascular Diseases Chemically-Induced Disorders Childhood Cancer Drug-Related Side Effects and Adverse Reactions Heart Diseases Neoplasms Pathologic Processes Pathological Conditions, Signs and Symptoms Radiation Injuries Wounds and Injuries

Age range

1 year–16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Xiao-Fan Zhu

Tianjin, Tianjin Municipality, 300000, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1. histological confirmed acute leukemia; 2. Preparing for chemotherapy;

Exclusion criteria

1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Treatment and study plan

Relative telomere length

Diagnostic Test

Relative telomere length in peripheral blood cell

Primary outcomes

Relative telomere length

Time frame: From date of admission until the date of discharging from hospital, assessed up to 5 days

The ratio of RTL to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from AL.

Sponsors and collaborators

Lead sponsor

Air Force Military Medical University, China

Other

Registry information

Official study title

Association Between Relative Telomere Length and Severity of Cardiac Dysfunction

Important dates

Study start: 2019
Primary completion: 2020
Study completion: 2020
First posted: Jun 1, 2020
Registry last updated: Jun 1, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed