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NCT Number: NCT07259837

Association Between Preoperative Health and Functional Status and Postoperative Complications in Elderly Patients

Using prospectively collected clinical data from the Chinese Perioperative Database of Elderly Patients, this study retrospectively analyzed patients aged ≥65 years who underwent elective non-cardiac, non-neurosurgical procedures under general anesthesia between April 2020 and April 2022. The study examined the associations between various preoperative health and functional status assessment tools and the occurrence of cardiovascular and cerebrovascular complications within 30 days after surgery, aiming to compare the clinical value of different assessment instruments.

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Key information

Conditions

Functional Status Older Adults (65 Years and Older) Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged ≥65 years;
  • Scheduled for elective non-cardiac, non-neurosurgical procedures;
  • Consented to undergo preoperative functional status and quality of life assessments.

Exclusion criteria

  • Had severe dementia, language disorders, significant hearing or visual impairments, or were in a coma;
  • Had Mini-Mental State Examination (MMSE) scores below the established educational thresholds: <18 for illiterate individuals, <21 for those with primary education (≤6 years), and <25 for those with secondary education or higher (>6 years);
  • Underwent local anesthesia or monitored anesthesia care;
  • Had an operative time ≤30 minutes;
  • Incompleted all the designated functional status and quality of life assessments.

Treatment and study plan

Primary outcomes

  1. The primary outcome was the occurrence of MACCE within 30 days after surgery.

    Time frame: Within 30 days after surgery.

    The primary outcome was the occurrence of MACCE within 30 days after surgery, defined as any of the following: stroke, myocardial infarction, angina pectoris, congestive heart failure, cardiac arrest, or all-cause mortality.[33] Postoperative complications were systematically assessed on days 1-5, 7, and 30, and continued until discharge. For discharged patients, outcomes were recorded via telephone follow-up, with diagnoses from the treating hospital. For MACCE, postoperative medical records of hospitalized patients were thoroughly reviewed according to the follow-up schedule, including serial measurements of serum myocardial injury biomarkers, electrocardiograms, echocardiograms, coronary angiography findings, postoperative progress notes, consultation records, and expert diagnostic evaluations.

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Official study title

Association Between Preoperative Health and Functional Status and Postoperative Complications in Elderly Patients: An Analysis of a Prospective Cohort

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Dec 2, 2025
Registry last updated
Dec 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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