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NCT Number: NCT07712211

Association Between Pain Catastrophizing and PONV in Laparoscopic Cholecystectomy Patients

This study aims to explore whether patients' tendency to exaggerate or focus on pain (pain catastrophizing) is related to experiencing nausea and vomiting after surgery. The study will include patients undergoing laparoscopic cholecystectomy. Before surgery, patients will answer questions measuring pain catastrophizing and rate their pain during intravenous cannulation. Nausea and vomiting will be assessed at various times during the first 24 hours after surgery. The results may help better understand how psychological factors affect postoperative symptoms.

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Key information

Conditions

Vomiting, Postoperative Nausea Nausea and Vomiting, Postoperative Neurologic Manifestations Pain Pain Catastrophizing Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Nausea and Vomiting Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Trabzon Kanuni Education and Research Hospital

Trabzon, Turkey (Türkiye)

Location status: Recruiting

Location contact

Sedanur sula

SUB_INVESTIGATOR

recep erin, doctor

CONTACT

[email protected]

+905304699135

About this study

This study is designed as a prospective, cross-sectional, and observational study. The Pain Catastrophizing Scale (PCS) is a well-established self-report instrument developed to assess catastrophic thinking related to pain. It evaluates how individuals perceive and respond to pain, focusing on tendencies such as rumination, magnification, and feelings of helplessness. Evidence suggests that PCS is a strong predictor of pain intensity, independent of anxiety levels. In this study, the validated Turkish version of the Pain Catastrophizing Scale will be used.

Postoperative nausea, vomiting, and retching are common adverse events that can complicate recovery from anesthesia. Patients often perceive these symptoms as more distressing than postoperative pain, and they represent important outcomes affecting patient satisfaction and recovery.

The present study aims to investigate the relationship between pain perception during intravenous (IV) cannulation, pain catastrophizing levels, and postoperative nausea and vomiting. By evaluating numeric pain scores during IV access alongside PCS scores, this study seeks to explore whether preoperative pain perception and psychological factors are associated with the frequency of postoperative nausea and vomiting.

The findings of this study are expected to contribute to a better understanding of the role of psychological factors in postoperative symptoms and may help improve anesthesia practices by supporting more individualized, patient-centered perioperative care.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients aged 18-65 years
  • American Society of Anesthesiologists (ASA) physical status I-II-III
  • Scheduled for elective laparoscopic cholecystectomy
  • Able to provide informed consent

Exclusion criteria

  • Age <18 or >65 years
  • Emergency surgery
  • ASA physical status > III
  • Pregnancy
  • Chronic opioid use
  • Known drug allergy
  • Psychiatric disorders
  • Neurological diseases (central or peripheral neuropathy)
  • History of cerebrovascular disease (stroke)
  • Chronic renal disease
  • Chronic pulmonary disease
  • Patients who refuse to participate

Treatment and study plan

Primary outcomes

  1. Incidence of postoperative nausea and vomiting (PONV)

    Time frame: Within 24 hours postoperatively

    The primary outcome is the incidence of postoperative nausea and vomiting (PONV) according to preoperative Pain Catastrophizing Scale (PCS) scores. Patients will be evaluated for PONV at 0, 3, 6, 12, and 24 hours postoperatively. The relationship between PCS scores and the frequency of PONV will be analyzed.

Secondary outcomes

  1. Association between IV cannulation pain and pain catastrophizing

    Time frame: Preoperative period

    The secondary outcome is the relationship between pain experienced during intravenous (IV) cannulation and preoperative Pain Catastrophizing Scale (PCS) scores. Pain during IV access will be measured using a numeric rating scale (0-10). The association between IV pain scores and PCS scores will be analyzed

Study contacts

Contact information is provided by the study sponsor or research team.

sedanur sula

CONTACT

[email protected]

+905424096196

Sponsors and collaborators

Lead sponsor

Trabzon Kanuni Education and Research Hospital

Other

Registry information

Official study title

The Relationship Between Pain Catastrophizing Scale and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Jul 17, 2026
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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