Association Between Oral Hypofunction, Sarcopenia and Social Frailty in Community-dwelling Older Adults

Previous studies have provided a preliminary understanding of the likelihood of sarcopenia and the prevalence of sarcopenia in the elderly in the community. due to the interaction between physiological and social factors, this study aims to conduct a correlation study on muscle mass, oral function and social frailty in the elderly living in the community.

This study，the Makizako social frailty screening index questionnaire and the Tilburg Frailty Indicator will be used to assess the social frailty status of the study participants. Correlation analysis with sarcopenia and oral dysfunction was also conducted to better understand the interaction between nutrition, physiology, and social connection in the elderly, which will be helpful for formulating relevant policies and promoting healthy aging in the future in extremely elderly countries.

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Key information

Conditions

Non Sarcopenic Subjects Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Possible Sarcopenia Sarcopenia Sarcopenia(With Low ASM by BIM) Signs and Symptoms

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chang Gung University of Science and Technology

Taoyuan, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Group A-Inclusion Criteria:

65 years old or above
general public or institutionalized for 3 months or more
those who accept the experimental design and are willing to sign the consent form
dietary sources are oral intake
those who are diagnosed as having possible sarcopenia by researchers

Group B-Inclusion Criteria:

65 years old or above
general public or institutionalized for 3 months or more
those who accept the experimental design and are willing to sign the consent form
dietary sources are oral intake
those who were determined by researchers to be non-probable sarcopenia

Group A、B-Exclusion Criteria:

comorbidities, critical illness, pre- and post-major surgery, cancer, renal failure, liver failure, kidney disease, liver disease, malignant tumors within the past five years, inflammatory conditions (c-reactive protein >10mg/dL)
severely malnourished people
long-term force-feeding

Treatment and study plan

Non interventional study

Other

NON

Primary outcomes

Based on the results of empirical research on sarcopenia in Asian countries, a diagnostic consensus was established.

Time frame: Baseline
- The cut-off point for abnormal grip strength is less than 28 kg for men and less than 18 kg for women
- 6-meter walking speed less than 1.0 second/meter
- 5-time chair stand test greater than or equal to 12 seconds
- Short physical performance battery, SPPB greater than or equal to 9 points The above will be combined to determine whether sarcopenia is possible.

Sponsors and collaborators

Lead sponsor

Chang Gung University of Science and Technology

Other

Registry information

Official study title

Association Between Oral Hypofunction, Sarcopenia, and Social Frailty in Community-Dwelling Older Adults

Acronym: OSSF

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jun 22, 2026
Registry last updated: Jun 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed