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OpenTrials
Completed

NCT Number: NCT02500823

Association Between Mitochondrial DNA Content and Risk of Coronary Heart Disease

Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of cardiovascular disease. This study was undertaken to investigate whether mtDNA copy number in peripheral blood cells could be used as a risk predictor for coronary heart disease.

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Key information

Conditions

Coronary Heart Disease Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Xijing Hospital

Xi'an, Shaanxi, 710032, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • History of documented myocardial infarction;
  • Prior coronary revascularization intervention (coronary artery bypass graft surgery or percutaneous coronary intervention);
  • The presence of ≥ 50% stenosis in one or more coronary arteries identified during cardiac catheterization;

Exclusion criteria

  • History of malignancy or end-stage renal disease;
  • Blood transfusion within one month or prior bone marrow transplantation
  • Patients who reluctant to sign informed consent

Treatment and study plan

Primary outcomes

  1. Relative copy number of mitochondrial DNA

    Time frame: From date of percutaneous coronary intervention until the date of discharging from hospital, assessed up to 5 days

    The ratio of mitochondrial DNA copy number to hemoglobin copy number was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA copy number.Relative copy number of Mitochondrial DNA were measured in CHD patients in comparison to control group.

Sponsors and collaborators

Lead sponsor

Air Force Military Medical University, China

Other

Registry information

Official study title

Association Between Mitochondrial DNA Copy Number in Peripheral Blood Cells and Risk of Developing Coronary Heart Disease

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Jul 17, 2015
Registry last updated
May 17, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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