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OpenTrials
Completed

NCT Number: NCT03595969

Association Between Mitochondrial DNA Content and Risk of Acute Leukemia

Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of acute lymphoblastic leukemia (ALL).The aim of this study was to explore association between mtDNA content in peripheral blood cells could be used as a risk predictor for ALL.

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Key information

Conditions

Lymphoblastic Leukemia in Children

Age range

Up to 16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Xiao-Fan Zhu

Tianjin, Tianjin Municipality, 300000, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1.histological confirmed chronic lymphocytic leukemia; 2.preparing for chemotherapy; 3.no preoperative anticancer treatment.

Exclusion criteria

  • 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Treatment and study plan

Relative copy number of mitochondrial DNA

Diagnostic Test

Mitochondria are responsible for multiple cellular functions including regulation of energy production, modulation of oxidation-reduction status, generation of reactive oxygen species and apoptosis. Each mitochondrion possesses multiple copies of a mitochondrial genome comprised of independently replicating double stranded DNA (mtDNA).

Primary outcomes

  1. Relative copy number of mitochondrial DNA

    Time frame: From date of admission until the date of discharging from hospital, assessed up to 5 days

    The ratio of mitochondrial DNA contents to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from chronic lymphocytic leukemiawhen compared with control group.

Sponsors and collaborators

Lead sponsor

Air Force Military Medical University, China

Other

Collaborators

  • Chinese Academy of Medical Sciences

Registry information

Official study title

Association Between Mitochondrial DNA Content and Risk of Acute Leukemia in Young Adult

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jul 23, 2018
Registry last updated
Jul 10, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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