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Completed

NCT Number: NCT07481006

Association Between Intraoperative Mean Arterial Pressure Variability and Postoperative Fatigue in Patients Undergoing Laparoscopic Abdominal Surgery

This prospective cohort study aims to investigate the relationship between intraoperative mean arterial pressure (MAP) variability and postoperative fatigue syndrome (POFS) in elderly patients (≥18 years) undergoing laparoscopic abdominal surgery. The main research question is:

Does the degree of intraoperative MAP fluctuation correlate with postoperative fatigue in elderly patients?

Eligible patients scheduled for elective laparoscopic abdominal surgery under general anesthesia will have their intraoperative blood pressure variability recorded (generalized average real variability, G-ARV), and postoperative fatigue and recovery will be assessed on postoperative days 1, 3, and 7 using the Christensen fatigue scale.

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Key information

Conditions

Fatigue Symptom Blood Pressure Variability Fatigue Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Lianyungang

Lianyungang, 博士, 222061, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years;
  • ASA physical status I-III;
  • Scheduled for elective laparoscopic abdominal surgery under general anesthesia.

Exclusion criteria

  • Severe cardiac, hepatic, or renal insufficiency, or major neurological or psychiatric disorders;
  • Known allergy to drugs used during the study;
  • Participation in other clinical trials within the past 3 months;
  • Unable to complete the required questionnaires or assessments;
  • Surgery duration < 60 minutes.

Treatment and study plan

Primary outcomes

  1. Postoperative Fatigue (Christensen Score)

    Time frame: Postoperative days 1, 3, and 7

    Primary outcome is the patient's fatigue level measured using the Christensen fatigue scale on postoperative days 1, 3, and 7. This scale evaluates overall fatigue severity including physical exhaustion, muscle weakness, and attention deficits after laparoscopic abdominal surgery.

Secondary outcomes

  1. Intraoperative Vasoactive Drug Use

    Time frame: During surgery

    Total dose of vasoactive drugs administered during surgery

  2. Postoperative Recovery Quality (QoR-15 Score)

    Time frame: Postoperative days 1, 3, and 7

    Postoperative recovery quality is assessed using the Quality of Recovery-15 (QoR-15) questionnaire on postoperative days 1, 3, and 7. The QoR-15 consists of 15 items, each scored from 0 (worst recovery) to 10 (best recovery). The total score ranges from 0 to 150, with higher scores indicating better postoperative recovery. Recovery quality can be categorized as excellent (136-150), good (122-135), moderate (90-121), and poor (0-89).

Sponsors and collaborators

Lead sponsor

The First People's Hospital of Lianyungang

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 18, 2026
Registry last updated
Jul 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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