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NCT Number: NCT06228729

Association Between EEG Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation

This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.

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Key information

Conditions

Abdominal Surgery Electroencephalogram Endotracheal Intubation Surgical Incision Surgical Wound Wounds and Injuries

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, 03080, South Korea

About this study

This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli.

Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation.
  • 2) Patients requiring invasive blood pressure monitoring during surgery

Exclusion criteria

  • 1) Patients transferred to the intensive care unit after surgery
  • 2) Surgery duration of less than one hour
  • 3) Patients with neurological underlying conditions
  • 4) Patients on chronic use of psychotropic medications and opioid drugs
  • 5) Emergency surgery

Treatment and study plan

Endotracheal Intubation

Procedure

Inserting endotracheal tube into the trachea

Primary outcomes

  1. Association between band power changes in EEG and hormone respones caused by endotracheal intubation

    Time frame: from the start of anesthesia induction to one minute after endotracheal intubation

Secondary outcomes

  1. Association between band power changes in EEG and hormone respones caused by surgical incision

    Time frame: from the start of anesthesia induction to one minute after surgical incision

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Evaluation of the Association Between Electroencephalographic Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation in Abdominal Surgery: a Prospective Observational Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jan 29, 2024
Registry last updated
Jan 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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