Association Between Confocal Laser Endomicroscopic (CLE) Features and Colorectal Mucosal Microbiome

The purpose of this study is to determine whether an association between endomicroscopic pattern and colorectal mucosal microbiome exists.

Completed

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Key information

Conditions

Colorectal Neoplasia Colorectal Inflammation Hyperplasia Mucosal Microbiome Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Gastroenterology, Qilu Hospital, Shandong University

Jinan, Shandong, 250012, China

About this study

The gut microbiome plays a pivotal role in the intestinal pathophysiology. The mucosal microbiome is in the front face of microbiome-host cross-talk. Confocal laser endomicroscopy (CLE) can provide realtime mucosal images during ongoing endoscopy. We hypothesized that the mucosal pattern, here evaluated by endomicroscopy, may constitute specific microbiome niches and participate the evolvement of the mucosal microbiome.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18 years old ≤ age < 80 years old
Scheduled for colonoscopy in Qilu Hospital

Exclusion criteria

antibiotic usage within 2 months
probiotic or prebiotic usage within 2 months
ascites
jaundice
liver cirrhosis
impaired renal function
coagulopathy
fever
pregnancy
breastfeeding
inability to provide informed consent
known allergy to fluorescein sodium

Treatment and study plan

the mucosal microbiome in the biopsy specimen was analysed

Other

Primary outcomes

The operational taxonomy unit in the colorectal mucosal microbiome.

Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Shandong University

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Feb 17, 2014
Registry last updated: Jun 30, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed