Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery

Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day. Neuropsychological testing before surgery and on 3 or 4 day after surgery. Investigation of relationship between changes of GFAP and scores of neuropsychological tests.

Completed

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Key information

Conditions

Astrogliosis Cognition Disorders Cognitive Dysfunction Confusion Delirium Emergence Delirium Gliosis Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications Postoperative Cognitive Dysfunction Postoperative Complications Postoperative Delirium Signs and Symptoms

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Moscow Clinical Scientific Center

Moscow, 111123, Russia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with different diseases, who require prolonged laparoscopy or open surgery
Age more than 60
ASA I-III
Informed consent to participate in the study

Exclusion criteria

ASA IV-V
Severe neurodegenerative or psychological diseases

Treatment and study plan

Glial fibrillary acidic protein

Diagnostic Test

3 samples of serum are drawn from patients. The 1st Sample of patient serum is drawn before induction into anesthesia. The 2nd is drawn 24 hours after the 1st one. The 3rd sample is drawn on 3 or 4 postoperative day. All samples collected and preserved in the same temperature as required for ELISA.

Primary outcomes

Changes in serum GFAP

Time frame: 1 year

GFAP(3) - GFAP (1); GFAP (2) - GFAP (1)

Sponsors and collaborators

Lead sponsor

Moscow Clinical Scientific Center

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2021
Study completion: 2021
First posted: Sep 25, 2018
Registry last updated: May 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed