Skip to main content
OpenTrials
Completed

NCT Number: NCT07198308

Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients

Heart rate variability (HRV) is a simple way to check how well the body's automatic nervous system is working. It does this by looking at how the heart rate changes in the electrocardiogram. HRV can be divided into time domain and frequency domain. Time domain indicators assess the tone of the autonomic nerves. Frequency domain indicators reflect the regulation of the sympathetic and parasympathetic nerves. An imbalance of the body's nervous system can be reflected by HRV. Stress hyperglycemia (SIH) is when your blood glucose levels go up because of an acute disease. This is usually related to the body's stress response, but if your blood glucose levels go up too much, it can lead to complications. A high blood sugar level caused by stress is common in intensive care units. There is a strong link between this and the death rate and how long patients stay there. There are lots of nerve endings in the pancreas. Nerve fibres control the way islet α/β cells work to keep the right amount of glucose in the blood. We know that the pancreatic nerve is important for controlling blood glucose levels, but we don't fully understand how it does this.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Zhongshan Hospital Fudan University

Shanghai, Shanghai Municipality, 200032, China

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged from 18 to 99 years old
  • Informed consent has been signed

Exclusion criteria

  • Under 18 years old
  • Diagnosed with diabetes either prior to or during hospitalization
  • Missing HRV values
  • Missing blood glucose and random insulin values

Treatment and study plan

Primary outcomes

  1. Correlation between glucagon and HRV in non-diabetic critically ill patients

    Time frame: From enrollment to completion of indicator testing (within 24 hours)

Secondary outcomes

  1. The correlation between blood glucose and random insulin levels and HRV in non-diabetic critically ill patients

    Time frame: From enrollment to completion of indicator testing (within 24 hours)

Sponsors and collaborators

Lead sponsor

Shanghai Zhongshan Hospital

Other

Registry information

Official study title

Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients: a Single-center Prospective Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Sep 30, 2025
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.