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Completed

NCT Number: NCT06248346

Association Between Administration of Dexmedetomidine and Postoperative Mortality in Hospitals

The present multicentre retrospective cohort study aimed to investigate the association between intraoperative administration of dexmedetomidine and postoperative mortality in hospitals.

The investigators set out to test the hypothesis that perioperative dexmedetomidine use, as an adjunct to general anesthesia, diminishes postoperative mortality in hospitals across all categories of surgical patients.

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Key information

Conditions

In-hospital Mortality

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients (aged ≥18 years)
  • undergo general anaesthesia with propofol
  • from January 1, 2014 to June 30, 2018

Exclusion criteria

  • patients undergoing intervention procedures under monitored anaesthesia care (MAC)
  • patients undergoing minor procedures under local or regional anaesthesia

Treatment and study plan

Dexmedetomidine

Drug

whether intraoperative dexmedetomidine was administered adjunct to propofol for patients undergoing surgeries under general anaesthesia

Primary outcomes

  1. in-hospital all-cause mortality

    Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year

    in-hospital deaths or discharged to hospice (or home)

Secondary outcomes

  1. length of postoperative hospital stay

    Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year

    in days

  2. admission to the intensive care unit (ICU)

    Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year

    unplanned admissions

  3. adverse events after surgery

    Time frame: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year

    severe stroke, the necessity for renal replacement therapy (RRT), myocardial infarction, ventilator-associated pneumonia (VAP), acute respiratory distress syndrome (ARDS), unplanned reoperation due to postoperative complications, sepsis, and multi-organ dysfunctions (MODs), if any

Sponsors and collaborators

Lead sponsor

Xijing Hospital

Other

Collaborators

  • First Hospital of China Medical University
  • Sir Run Run Shaw Hospital
  • The Affiliated Hospital of Qingdao University
  • The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Registry information

Official study title

Association Between Administration of Dexmedetomidine and Postoperative Mortality in Hospitals Among Inpatients Undergoing Surgeries Under General Anaesthesia Using Propofol

Important dates

Study start
2014
Primary completion
2018
Study completion
2018
First posted
Feb 8, 2024
Registry last updated
Feb 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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