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NCT Number: NCT07678606

Association Between 4D MRI Parameters and the Clinical Characteristics and Prognosis of Major Chronic Diseases

Cancer and cardiovascular diseases are among the leading causes of morbidity and mortality worldwide. Advanced imaging techniques such as 4D magnetic resonance imaging (MRI) enable quantitative assessment of hemodynamic and functional parameters beyond conventional imaging. The aim of this study is to evaluate the association between 4D MRI derived parameters and the occurrence, severity, and prognosis of major chronic diseases, and to explore their potential role as imaging biomarkers.

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Key information

Conditions

Cardiovascular Disease Cardiac Magnetic Resonance Imaging Cardiovascular Diseases Neoplasm Neoplasms

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

This is a single-center, prospective, observational registry study conducted at Ulsan University Hospital. The study will enroll 1,000 adult patients (≥ 19 years) undergoing cardiac MRI as part of routine clinical care in Korea.

Participants will undergo an additional 4D MRI sequence during the same imaging session, which does not affect clinical decision-making or patient management.

The primary objective of this study is to evaluate the association between quantitative imaging parameters derived from 4D MRI and the occurrence, severity, and prognosis of major chronic diseases.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 19 years and older undergoing clinically indicated Cardiac MRI at Ulsan University Hospital
  • Participants who undergo an additional 4D MRI sequence during the same imaging session
  • Participants who are able to understand the study and provide written informed consent

Exclusion criteria

  • Individuals aged < 19 years
  • Individuals with cognitive impairment or communication difficulties unable to provide informed consent
  • Poor-quality MRI images that are not suitable for analysis
  • Individuals deemed inappropriate for study participation by the investigator

Treatment and study plan

Primary outcomes

  1. Incidence of Major Adverse Cardiovascular Events (MACE)

    Time frame: up to 10 years

    Incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure during the follow-up period

Secondary outcomes

  1. Peak Wall Shear Stress

    Time frame: Perioperative/Periprocedural

    peak wall shear stress measured in the ascending aorta using 4D flow MRI

  2. Blood Flow Eccentricity

    Time frame: Perioperative/Periprocedural

    Blood Flow Eccentricity assessed in the ascending aorta using 4D flow MRI

Study contacts

Contact information is provided by the study sponsor or research team.

Gyung-Min Park MD, PhD

CONTACT

[email protected]

82-52-250-8993

Sponsors and collaborators

Lead sponsor

Ulsan University Hospital

Other

Registry information

Acronym: 4D-MRI

Important dates

Study start
2026
Primary completion
2036
Study completion
2046
First posted
Jul 1, 2026
Registry last updated
Jul 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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