ASSIST Registry Studying Various Operator Techniques

This measure assesses clinical outcome using the Modified Rankin Scale (mRS). Modified Rankin Scale measures the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. It is a score ranging from 0-6 with the following degree of disability: 0 = No symptoms at all; no limitations and no symptoms; 1 = No significant disability, 2 = Slight disability; 3 = Moderate disability; 4 = Moderate severe disability, 5 = Severe disability; 6= Death. The lower mRS Score indicates less disability, and higher score indicates increased disability.

This outcome measures percentage of subjects who achieved complete reperfusion after the first pass, defined by eTICI score of 2c or greater. Independent Imaging Core Lab adjudicated the outcome using the Expanded Treatment in Cerebral Infarction (eTICI) scale. The higher eTICI score indicates successful revascularization.

The Expanded TICI (eTICI) Perfusion Score Categories are:

• 0: Equivalent to no reperfusion or 0% filling of the downstream territory
• 1: Reflects thrombus reduction without any reperfusion of distal arteries
• 2a: Reperfusion in less than half or 1-49% of the territory
• 2b50: 50-66% reperfusion
• 2b67: 67-89% reperfusion
• 2c: 90-99% reperfusion
• 3: Complete or 100% reperfusion

Percentage of subjects with an excellent functional outcome of mRS of 0-1 at Day 90 (± 14).

Modified Rankin Scale measures the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. It is a score ranging from 0-6 with the following degree of disability: 0 = No symptoms at all, no limitations and no symptoms; 1 = No significant disability, 2 = Slight disability; 3 = Moderate disability; 4 = Moderate severe disability, 5 = Severe disability; 6= Death. The lower mRS Score indicates less disability.

Percentage of subjects with an "early response" at Discharge/Day5-7 (whichever is earlier) defined as a NIHSS drop of ≥10 points from baseline or NIHSS score of 0 or 1.

NIHSS (National Institutes of Health Stroke Scale) is an assessment to objectively quantify the impairment caused by a stroke. It is composed of 11 items, each of which scores a specific ability. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. The individual scores from each item are summed in order to calculate a total NIHSS score. The maximum possible score is 42, with the minimum score being a 0.

The Euro Quality of Life Questionnaire - 5 Level 5D Version (EQ5D5L) is composed of 5 dimensions- mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension is evaluated by the subject on 5 level scale: no problems, slight problems, moderate problems, severe problems and extreme problems. The outcome reported shows severe and extreme levels were combined and only 4 levels are reported.

This outcome reports percentage of subjects who achieved eTICI 2b50, eTICI 2b67, eTICI 2c,or eTICI 3 on first pass after primary technique used and at the end of the endovascular procedure.

Independent Imaging Core Lab adjudicated the outcome using the Expanded Treatment in Cerebral Infarction (eTICI) scale. The higher eTICI score indicates successful revascularization.

The Expanded TICI (eTICI) Perfusion Score Categories are:

• 0: Equivalent to no reperfusion or 0% filling of the downstream territory
• 1: Reflects thrombus reduction without any reperfusion of distal arteries
• 2a: Reperfusion in less than half or 1-49% of the territory
• 2b50: 50-66% reperfusion
• 2b67: 67-89% reperfusion
• 2c: 90-99% reperfusion
• 3: Complete or 100% reperfusion

This outcome measures overall time (in minutes) observed from groin puncture to the specific eTICI reperfusion score at end of first pass for treatment of target occlusion. Each subject can only be in one eTICI category and therefore they are mutually exclusive.

Independent Imaging Core Lab adjudicated the outcome using the Expanded Treatment in Cerebral Infarction (eTICI) scale. The higher eTICI score indicates successful revascularization.

The Expanded TICI (eTICI) Perfusion Score Categories are:

• 0: Equivalent to no reperfusion or 0% filling of the downstream territory
• 1: Reflects thrombus reduction without any reperfusion of distal arteries
• 2a: Reperfusion in less than half or 1-49% of the territory
• 2b50: 50-66% reperfusion
• 2b67: 67-89% reperfusion
• 2c: 90-99% reperfusion
• 3: Complete or 100% reperfusion

This outcome measures the overall time (in minutes) observed from groin puncture to final reperfusion of eTICI 2c or 3 for treatment of target occlusion.

Independent Imaging Core Lab adjudicated the outcome using the Expanded Treatment in Cerebral Infarction (eTICI) scale. The higher eTICI score indicates successful revascularization.

The Expanded TICI (eTICI) Perfusion Score Categories are:

• 0: Equivalent to no reperfusion or 0% filling of the downstream territory
• 1: Reflects thrombus reduction without any reperfusion of distal arteries
• 2a: Reperfusion in less than half or 1-49% of the territory
• 2b50: 50-66% reperfusion
• 2b67: 67-89% reperfusion
• 2c: 90-99% reperfusion
• 3: Complete or 100% reperfusion

Prespecified safety outcome measures include all-cause mortality and stroke-related mortality up to 90 days (±14), device and/or procedure related SAEs up to 90 Days (±14), neurological deterioration at 24 hours post procedure, embolization to new territory adjudicated by core lab. and neurological deterioration at 24 hours post-procedure to 48 hours