Assessment of Traumatic Brain Injury Using Transcranial Magnetic Stimulated Evoked Potentials

Inclusion criteria

for Traumatic Brain Injury (Acute, Subacute, Chronic) group:

• Age 18 years and older
• Evidence of mechanical energy impacting the head or inertial forces affecting the head
• Either (A) or (B):

• Trauma-related abnormality on CT scan on admission
• If CT normal, documented/verified TBI based on evidence of either loss of consciousness, post-traumatic amnesia, confusion, or post-traumatic symptoms.

Exclusion criteria

for Traumatic Brain Injury (Acute, Subacute, Chronic) group:

• History of disabling pre-existing neurologic disease (Such as epilepsy, brain tumors, meningitis, cerebral palsy, encephalitis, brain abscesses, vascular malformations, cerebrovascular disease, Alzheimer's disease, multiple sclerosis, or HIV-encephalitis)
• History of premorbid disabling condition that interfere with outcome assessments
• Bilaterally absent pupillary responses
• Penetrating traumatic brain injury
• Prisoners or patients in police custody
• Pregnancy
• Subjects with magnetic-sensitive devices implanted in their head or within 12 in. (30 cm) of the coil/probe (examples: cochlear implants, deep brain stimulators, vagus nerve stimulators, other implanted electrodes/stimulators, aneurysm clips or coils, stents and bullet fragments).

Inclusion criteria

for Healthy Control group:

• Age 18 years and older
• No history of TBI in the past 12 months

Exclusion criteria

for Healthy Control group:

• History of disabling pre-existing neurologic disease (Such as epilepsy, brain tumors, meningitis, cerebral palsy, encephalitis, brain abscesses, vascular malformations, cerebrovascular disease, Alzheimer's disease, multiple sclerosis, or HIV-encephalitis)
• History of premorbid disabling condition that interfere with outcome assessments
• Prisoners or patients in police custody
• Pregnancy
• Subjects with magnetic-sensitive devices implanted in their head or within 12 in. (30 cm) of the coil/probe (examples: cochlear implants, deep brain stimulators, vagus nerve stimulators, other implanted electrodes/stimulators, aneurysm clips or coils, stents and bullet fragments).