Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease

The presence of a specific mutation in the gene known as B-RAF has been found in patients who have Hairy Cell Leukemia. In this study this specific mutation known as V600E will be ascertained in peripheral blood samples of patients who have this disease and in a group of patients who have a similar chronic lymphoproliferative conditions such as splenic marginal lymphoma. The finding of this specific mutation will help to verify or exclude the diagnosis of Hairy Cell Leukemia and determine whether patients are in remission.

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Key information

Conditions

Hairy Cell Leukemia Hematologic Diseases Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Leukemia Leukemia, Hairy Cell Lymphatic Diseases Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type Splenic Marginal Zone Lymphoma

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients over the age of 18 years -

Exclusion criteria

Patients less than 18 years in age or mentally defectives.

Treatment and study plan

Primary outcomes

detection of the B-RAF V600E mutation

Time frame: 2 weeks

Sponsors and collaborators

Lead sponsor

HaEmek Medical Center, Israel

Other

Registry information

Official study title

Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease.

Acronym: B-RAF V600E

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2013
First posted: Nov 2, 2012
Registry last updated: Aug 11, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed