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NCT Number: NCT07746102

Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease

The aim of our study is to evaluate the impact of repeated episodes of ischemic quenching on changes in blood pressure, heart rate and laboratory parameters of inflammation in patients with kidney diseases. There is credible evidence that intentionally producing periods of ischemia provides protection of the myocardium and blood vessels against subsequent ischemic injury. The examination will be performed during hospitalization in the Department of Nephrology, Hypertension, Transplantology and Internal Diseases and will last 4 days. On the first day, blood pressure will be measured using an automatic blood pressure monitor, radial artery pulse, blood saturation will be measured using a pulse oximeter, and approximately 6 ml of venous blood will be collected from the elbow bend area for laboratory tests. Then, compression of the lower limb below the knee will be performed using a blood pressure cuff. Four 5-minute cycles of inflation and deflation of the cuff will be performed. The pressure on the lower limb will be repeated on the next two days. On the last day of the examination, blood pressure, heart rate and blood saturation will be measured again, and approximately 6 ml of venous blood will be collected again for laboratory tests.

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Key information

Conditions

Hemodialysis Blood Pressure Disorders Chronic Disease Chronic Kidney Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Inflammation Ischemia Preconditioning Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical University of Lodzi, Lodz, Poland

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • obtaining the patient's voluntary, informed consent to participate in the experiment,
  • chronic kidney disease in stages G1-G5,
  • women and men over 18 years of age.
  • failure to meet the qualification criteria for participation in the study,
  • consciousness disorders,
  • heart failure (NYHA IV),
  • severe anemia (Hb concentration<8g/dL),
  • features of muscle cell damage (e.g. rhabdomyolysis),
  • peripheral circulation disorders, peripheral vascular diseases.

Exclusion criteria

-

Treatment and study plan

Preconditioning with control ischemic episodes

Other

4 cycles of 5-minute inflation and deflation using a sphygmomanometer cuff at a pressure of 30 mmHg above the systolic value through three consecutive days

Primary outcomes

  1. Assessment of changes of parameter: Measurement of SIRT-1 [ng/]

    Time frame: 7 days

    Measurement of SIRT-1 [ng/] at the beginning and 7 days

  2. Assessment of changes of parameter blood saturation [%].

    Time frame: 7 days

    at the beginning and 7 days

  3. Assessment of IL-6

    Time frame: 7 days

    Measurement of IL-6 [ng/ml] at the beginning and 7 days.

  4. Assessment of Blood pressure

    Time frame: 7 days

    Blood pressure [mmHg] will be checked at the beginning and 7 days

  5. Assessment of heart beat/min

    Time frame: 7 days

    will be checked at the beginning and 7 days

Study contacts

Contact information is provided by the study sponsor or research team.

Katarzyna Pęczek-Bartyzel, MD PhD

CONTACT

[email protected]

+48 42 201 44 00

Michał Nowicki, Professor

CONTACT

[email protected]

+48 42 201 44 00

Sponsors and collaborators

Lead sponsor

Medical University of Lodz

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 4, 2026
Registry last updated
Aug 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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