Assessment of the Impact of Acquisition Time, Respiratory Gating and New Qclear Reconstruction Modalities on the Quantification of Dosimetry in Selective Internal Radiotherapy

Post-processing of Positron Emission Tomography (PET) acquired images, performed following radioembolization treatment with microspheres at 90Y in hepatocellular carcinoma patients, is subject to changes commercialized by General Electric : respiratory motion correction, specific reconstruction algorithms. We propose to test the possible combinations of these reconstruction parameters to determine which ones to apply for an optimal quality exam with the shortest scan time possible

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Key information

Conditions

Carcinoma, Hepatocellular Adenocarcinoma Carcinoma Digestive System Diseases Digestive System Neoplasms Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Bordeaux

Bordeaux, 33076, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patient with hepatocellular carcinoma
with radioembolization treatment decided
over the age of 18

Exclusion criteria

radiembolization not possible
acquisition of PET/CT imaging at 90Y not possible

Treatment and study plan

PET/CT Exam

Procedure

PET/CT image processing application of reconstruction parameters: scan time, respiratory gating, Q-clear

Primary outcomes

Average dose value (Gy) of tumor liver and healthy liver obtained according to reconstruction configuration.

Time frame: Day 0 (PET/CT Exam)

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Collaborators

GE Healthcare

Registry information

Acronym: PYR

Important dates

Study start: 2021
Primary completion: 2021
Study completion: 2021
First posted: May 26, 2021
Registry last updated: Mar 31, 2022

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed