Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele

Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.

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Key information

Conditions

Varicocele Cardiovascular Diseases Genital Diseases Genital Diseases, Male Infertility Infertility, Male Male Urogenital Diseases Urogenital Diseases Vascular Diseases

Age range

18 year–39 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Benha Faculty of Medecine, Banhā, Egypt

About this study

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Infertile men
Varicocele
Poor sperm parameters

Exclusion criteria

Men with systemic diseases
Infertile men due to other causes than varicocele

Treatment and study plan

Varicocelectomy

Procedure

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition

Primary outcomes

The Quality of Semen

Time frame: 6 months
According to WHO 2010 guidelines regarding semen analysis
- Sperm concentration (to be more than 15 million sperm per milliliter).
- Sperm motility (not less than 60% progressive motility).
- Sperm morphology (not less than 6% normal morphology).

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2020
Study completion: 2020
First posted: Apr 23, 2021
Registry last updated: Apr 23, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed