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NCT Number: NCT07107347

Assessment of Right Ventricular Function After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters

Echocardiographic Assessment:

Performed within 24h of PE diagnosis Conventional parameters: TAPSE, RV FAC, RV/LV ratio, tricuspid S', PASP STE parameters: RV free wall longitudinal strain (RVFWS), global longitudinal strain (GLS) if feasible All measurements averaged over 3 cardiac cycles (sinus) or 5 (AF)

Follow-up data:

ICU/hospital LOS Need for vasopressors/mechanical ventilation In-hospital and 30-day mortality

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Key information

Conditions

Acute Pulmonary Embolism (PE)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

the study targets patient with acute pulmonary embolism confirmed by CTPA, without hemodynamic instability. within the first 24 hours echocardiography will be conducted, assessment of RV function by conventional measures eg, TAPSE, S', FCA and speckle tracking strain echocardiography.

compare the results and its sensitivity in prediction of clinical outcomes, that will be assessed by follow up the patients for one month regarding length of hospital stay, oxygen/ventilatory support, hemodynamics support and 30 day mortality.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults ≥18 years.
  • Confirmed acute PE (via CT pulmonary angiography).(4,6)
  • Echocardiography performed within 24 hours of diagnosis.

Exclusion criteria

  • Pre-existing significant RV dysfunction (e.g., due to chronic pulmonary hypertension, cor pulmonale or congenital heart disease).
  • History of coronary artery disease.
  • Impaired LV systolic function, ejection fraction <50%.
  • Moderate to severe valvular heart disease.
  • Prior document of an episode of pulmonary embolism.
  • Poor acoustic window.
  • Hemodynamic instability

Treatment and study plan

Primary outcomes

  1. Primary (main): Composite of in-hospital mortality, ICU admission >7 days, or need for mechanical circulatory/ventilatory support.

    Time frame: 30 day follow up

Secondary outcomes

  1. Secondary outcome: Each individual component; echocardiographic parameters as predictors.

    Time frame: 30 day follow up

Study contacts

Contact information is provided by the study sponsor or research team.

Doaa Roshdy, assistant lecturer

CONTACT

[email protected]

+201024588594

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Assessment of Right Ventricular Function for Diagnosis and Prognosis After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Aug 6, 2025
Registry last updated
Aug 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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