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Completed

NCT Number: NCT03644901

Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes.

The aim of this study is to find out if one blood group phenotype is more responsive than the others to the nonsurgical periodontal treatment.

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Key information

Conditions

Chronic Periodontitis Chronic Disease Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Periodontics

Damascus, DM20AM18, Syria

About this study

To the best of our knowledge, this is the first (research) randomized clinical trial that assesses how patient respond to the nonsurgical periodontal treatment based on their blood group phenotype.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • systematically healthy.
  • have at least 20 teeth excluding the third molars.
  • had not received any periodontal treatment or antibiotic therapy for dental or medical reason 6 month prior to the study.
  • diagnosed with generalized chronic periodontitis (>30% of the sites have probing depth ≥4), and a minimum of six teeth with probing depth of 5-6 mm.

Exclusion criteria

  • smokers and alcoholics.
  • pregnancy.
  • history of a systematic disease such as diabetes, leukemia, epilepsy.
  • participants who are unable to perform routine oral hygiene.
  • use of orthodontic appliances.
  • participants who are unable to perform routine oral hygiene.

Treatment and study plan

Nonsurgical periodontal treatment

Procedure

patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.

Other names: Conventional periodontal treatment, scalling and root planing

Primary outcomes

  1. Change in relative attachment level.

    Time frame: measures will be taken at baseline and after two months from treatment.

    the relative attachment level measures the length form the base of the periodontal pocket to a stent

Secondary outcomes

  1. Change in periodontal probing depth.

    Time frame: measures will be taken at baseline and after two months from treatment.

    the distance between the gingival margin to the base of the periodontal pocket.

  2. Change in gingival index

    Time frame: index will be taken at baseline and after two months from treatment.

    it is used to designate the level of the gingival inflammation.

  3. Change in plaque Index

    Time frame: index will be taken at baseline and after two months from treatment.

    it is used to designate the level of plaque accumulation.

Sponsors and collaborators

Lead sponsor

Damascus University

Other

Registry information

Official study title

Investigating the Role of ABO Blood Group in the Response to the Nonsurgical Periodontal Treatment.

Important dates

Study start
2018
Primary completion
2018
Study completion
2019
First posted
Aug 23, 2018
Registry last updated
Mar 13, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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