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NCT Number: NCT06876974

Assessment of Prognosis and Myocardial Reperfusion in Patients with ST-segment-elevation Myocardial Infarction (STEMI) According to Coronary Atherosclerotic Burden.

In the current literature, it has been widely demonstrated that the extend of coronary atherosclerotic burden is associated with adverse long-term outcomes. Little is known about the impact of atheroma burden and either myocardial reperfusion and short-term outcomes after ST-segment elevation myocardial infarction (STEMI). Several angiographic scores have been used to measure the extend and severity of coronary atheroma. The SYNTAX score and the Gensini score have been shown to be independent predictors of cardiovascular events and mortality in stable coronary artery disease as well as in myocardial infarction.

This research therefore aims to assess the impact of overall coronary atherosclerotic burden, measured by two angiographic scores (SYNTAX score and Gensini score), both before and after primary percutaneous angioplasty, in patients with STEMI according to different clinical subgroups.

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Key information

Conditions

STEMI - ST Elevation Myocardial Infarction (MI) Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients presenting with STEMI and treated with primary PCI (pPCI) at the University Hospital of Nancy between 2003 and 2023.

Exclusion criteria

  • patients with missing or incomplete coronary angiogram.

Treatment and study plan

Primary outcomes

  1. All-cause mortality

    Time frame: 2 years

    all-cause mortality at 45 days, 1 year and 2 years

  2. Recurrent acute coronary syndrome

    Time frame: 1 year

    Recurrent acute coronary syndrome at 1-year

Secondary outcomes

  1. All-cause mortality in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock

    Time frame: 2 years

    All-cause mortality at 45 days, 1 year and 2 years in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock

  2. Recurrent acute coronary syndrome in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock

    Time frame: 1 year

    Recurrent acute coronary syndrome at 1 year in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 14, 2025
Registry last updated
Mar 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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