Assessment of Neuropathic Pain

Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases. The functionality of the pain pathway in humans as well as its plastic changes following SCI can be assessed in vivo by surface electrophysiological recordings and functional magnetic resonance imaging after noxious heat stimulation of the skin. Aims: a) establishing a clinically applicable assessment of the pain pathway and characterizing its changes as a consequence of SCI and in peripheral nerve diseases in an objective manner, b) characterizing plastic changes in the pain pathway in SCI patients with neuropathic pain and in patients with peripheral nerve diseases and relating them to the development of neuropathic pain syndromes.

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Key information

Conditions

Spinal Cord Injury + Peripheral Nerve Diseases Central Nervous System Diseases Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Spinal Cord Diseases Spinal Cord Injuries Trauma, Nervous System Wounds and Injuries

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Curt, Armin, MD

Zurich, Canton of Zurich, 8008, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Uninjured
Scord injured subjects
Subjects with peripheral nerve diseases
Patients resident in Switzerland

Exclusion criteria

Presence of any central psychiatric disorder (that precludes subject from giving informed and voluntary consent)
For fMRI measurements: "yes" for any item in the MR-risk questionnaire
Patients resident outside from Switzerland

Treatment and study plan

Primary outcomes

Pain, sensory and autonomic assessments

Time frame: 2 - 4 weeks

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Important dates

Study start: 2006
Primary completion: 2024
Study completion: 2024
First posted: May 14, 2014
Registry last updated: Jan 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed