Assessment of Left Ventricular Myocardial Dysfunction in Children With End-Stage Kidney Disease Using Two-Dimensional and Three-Dimensional Speckle-Tracking Echocardiography

The present study aimed to assess left ventricular myocardial dysfunction in children with chronic kidney disease using 2D and 3D speckle-tracking echocardiography.

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Key information

Conditions

Left Ventricular Myocardial Dysfunction Children Chronic Disease Disease Attributes End-stage Kidney Disease Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Three-Dimensional Speckle-Tracking Echocardiography Two-Dimensional Speckle-Tracking Echocardiography Urogenital Diseases Urologic Diseases

Age range

4 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Al-Azhar University

Cairo, 11651, Egypt

About this study

Chronic kidney disease (CKD) is a complex and multifaceted disease that causes renal dysfunction and progression to end-stage kidney disease.

Cardiovascular risk is common in patients with end-stage renal disease on hemodialysis, many studies have shown that the risk of adverse cardiovascular events is significantly increased and persistent in all patients treated with hemodialysis, especially those who have just started hemodialysis treatment.

Patients with end-stage renal disease have elevated levels of cardiac biomarkers, despite no apparent signs of cardiac dysfunction or radial damage; this is related to chronic kidney disease comorbidities and reduced renal clearance per se.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age between 4 and 18 years.
Children with chronic kidney disease (CKD) receiving regular hemodialysis for ≥1 year.

Exclusion criteria

Presence of structural or congenital heart disease.
Patients with poor echocardiographic window or arrhythmias interfering with image acquisition.

Treatment and study plan

Two-Dimensional Speckle-Tracking Echocardiography (2D-STE)

Device

2D speckle-tracking echocardiography was used to assess left ventricular myocardial deformation. Standard apical four-, two-, and three-chamber views were acquired with optimized frame rates.

Three-Dimensional Speckle-Tracking Echocardiography (3D-STE)

Device

Three-dimensional datasets were acquired from apical full-volume images, ensuring optimal electrocardiographic gating, adequate frame rates, and high-quality image acquisition.

Primary outcomes

Left ventricular systolic function

Time frame: At baseline

Left ventricular systolic function was evaluated by calculating the left ventricular ejection fraction (LVEF) using the biplane Simpson's method from apical four- and two-chamber views.

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Jul 1, 2026
Registry last updated: Jul 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed