Assessment of Language Disorders in Multiple Sclerosis Patients

Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis.

Experimental tasks based on psycholinguistics and functional MRI are not standardized tests. To be able to interpret the results of patients, they must therefore be compared with healthy controls of the same age (+/-3 years) and level of education.

This study will require the inclusion of cases and controls matched to these cases on the above characteristics.

Patients who are seen in consultation or day hospitalization and who meet the inclusion and non-inclusion criteria will be offered the opportunity to participate in the study. Accompanying persons accompanying patients "matching" with included patients who meet the inclusion and non-inclusion criteria will also be offered the opportunity to participate in the study.

Inclusion visit (D0) :

• Completion of the HAD self-questionnaire
• Validation of inclusion and exclusion criteria
• Signature of consent
• Collection of socio-demographic data to adjust standardized test results (age, gender, socio-economic and education level)
• Completion of the computerized ECVB self-questionnaire with the help of a clinical research technician: only for cases
• Scheduling of the HDJ assessment day (maximum 6 months after the inclusion visit)

Visit 1 (assessment in HDJ) (D0 + 6 months maximum) :

• Neurological examination of the patient and performance of an EDSS if necessary
• Battery of standardised and normalised tests evaluating different cognitive functions (Annexes 1 and 2 to 9): only for cases
• Experimental language tasks (see description in section 6): for cases and controls
• Non-injected structural and functional encephalic MRI: only for cases with language impairment detected in the examination battery (and their matched controls)

Criteria for inclusion of cases :

• Patient with a diagnosis of RRMS or MS according to the Mac Donald criteria 2017
• Patient between 18 and 60 years old inclusive
• Express consent to participate in the study
• Affiliate or beneficiary of a social security scheme
• Patients in structured computerised databases for MS

Criteria for non-inclusion of cases

• Pregnant or breastfeeding woman
• Patient with a psychological disorder that may induce a language disorder (AHH - anxiety score ≥ 8 or AHH - depression score ≥ 8) (scale in Appendix 11)
• Patient with a history of language impairment before the onset of MS
• Patient receiving speech therapy for language disorders
• Patient whose mother tongue is not French
• Patient with too much dysarthria hindering the intelligibilité́ of his words
• Patient with uncorrected visual and/or hearing impairment
• Neurological diseases (other than MS)
• Psychiatric disorders
• Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker).

Criteria for inclusion of witnesses

• Person matched to a "case" on age (+/-3 years) and education level (see Annex 11)
• Express consent to participate in the study
• Affiliate or beneficiary of a social security scheme

Criteria for non-inclusion of witnesses

• Pregnant or breastfeeding woman
• Psychic disorder that can induce a language disorder (AHH - anxiety score ≥ 8 or AHH - depression score ≥ 8) (Appendix 10)
• History of Language Impairment
• Person receiving speech therapy for language disorders
• Person whose mother tongue is not French
• Person with too much dysarthria hindering the intelligibilité́ of his words
• Uncorrected visual and/or hearing impairment
• Person with a neurological disease
• Psychiatric disorders
• Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker).