Assessment of International Normalized Ratio (INR) Prolongation in Patients Treated Simultaneously With Warfarin and Cephalosporins

Many drug interactions with Warfarin are well documented in the literature, including interactions with a variety of antibiotics. However,in mamy cases it is difficult to predict when the interaction remains theoretical and when it becomes clinically significant and will be reflected in the individual patient. This study's aim is to identify and characterize related conditions (including comorbidities, laboratory test results and other parameters related to the patient)that might be predictors for drug interactions turning from theoretical to clinically significant.

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Key information

Conditions

Venous Thrombosis Arrhythmias, Cardiac Atrial Fibrillation Cardiovascular Diseases Embolism Embolism and Thrombosis Heart Diseases Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Embolism Respiratory Tract Diseases Thrombosis Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18 and over
Patients treated with a combination of Warfarin and Cephalosporins
Patients who were hospitalized in the department of internal medicine
Patients who were treated with Warfarin without Cefalosporins

Exclusion criteria

Patients on Warfarin who did not actually receive the drug during their hospitalization
Patients whose medical records were not accessible or didn't contain full data

Treatment and study plan

Primary outcomes

Reasons for INR prolongation in patients who were treated with the combination of Warfarin and Cephalosporins

Time frame: Participants will be followed for the duration of thei hospital stay, an expected average of 7 days

Sponsors and collaborators

Lead sponsor

Meir Medical Center

Other

Registry information

Official study title

Assessment of INR Prolongation in Patients Treated Simultaneously With Warfarin and Antibiotics From the Cephalosporins Family,Observational Retrospective Study.

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: May 20, 2013
Registry last updated: Feb 25, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed