Fortrea Clinical Development
Leeds, LS11 9EH, United Kingdom
NCT Number: NCT06444178
This study is researching experimental drugs called REGN9933 and REGN7508 (called "study drugs") and comparing their effects to approved treatments of rivaroxaban and aspirin (called "standard treatments"). Aspirin will be given alone or in combination with the study drugs or the other standard treatments to look at their effects on blood loss in the intestines.
The aim of the study is to see if aspirin alone or the study drugs REGN9933 and REGN7508, when taken with aspirin, cause less minor intestinal bleeding than standard treatments rivaroxaban with aspirin.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Looking for future studies?
Notify Me18 year–55 year
All sexes
Interventional
Phase 1
Leeds, LS11 9EH, United Kingdom
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Key Inclusion Criteria:
Key Exclusion Criteria:
Note: Other Protocol Defined Inclusion/ Exclusion Criteria Apply
Oral administration
Administered intravenous (IV)
Administered IV
Oral administration
Time frame: Baseline and up to day 22
Time frame: Up to day 100
Time frame: Up to day 100
Time frame: Up to day 100
Time frame: Up to day 100
Time frame: Up to day 29
Time frame: Up to day 29
Time frame: Baseline and up day 29
Time frame: Baseline and up day 29
Time frame: Up to day 29
Time frame: Up to day 29
Time frame: Up to day 29
Time frame: Up to day 29
Regeneron Pharmaceuticals
Industry
A Parallel Group Study in Healthy Participants to Quantitate Increases in Subclinical Gastrointestinal Blood Loss Following Administration of Aspirin Alone or in Combination With Rivaroxaban or Factor XI Inhibitors (REGN9933 or REGN7508)
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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