Assessment of Functional and Symptom Outcomes for Survivors of Paranasal Sinus, Nasopharyngeal and Skull Base Tumors

Objectives:

• To estimate the prevalence and severity of adverse and functional outcomes in survivors of benign and malignant paranasal sinus, nasopharynx and skull base tumors.
• To estimate the prevalence of health promotion behaviors during skull base tumor survivorship
• To identify possible mediators or predictors of survivorship outcomes and health behaviors in survivors of skull base tumors.
• To develop a database of demographic, clinicopathologic, recurrence, survival, functional and patient reported outcomes (PROS) for patients with benign and malignant paranasal sinus, nasopharyngeal and skull base tumors.
• To assess the utility and limitations of PROs in evaluating functional impairments and symptom burden in skull base patients.

Inclusion criteria

• Previously untreated patients with or suspected to have sinonasal malignancy or nasopharyngeal malignancy diagnosis based on either outside pathology report or MD Anderson pathology report.
• Age ≥ 18 years
• Plan to obtain the majority of treatment at MDACC including surgery and radiotherapy
• Ability to understand and willingness to sign written informed consent

Exclusion criteria

• History of the previous solid or liquid malignancies, apart from skin cancers treated with local therapy.
• Existing neurocognitive impairment that is not the result of sinonasal and nasopharyngeal cancers or is treatment.
• Previous treatment for sinonasal or nasopharyngeal carcinomas, apart from biopsy.