AssesSment of Early-deteCtion basEd oN liquiD Biopsy in Hepatobiliary Cancer Malignancies

Inclusion criteria

for All the Participants:

• 40-75 years old
• Ability to comply with study procedures
• Ability to provide a written informed consent

Exclusion criteria

for All the Participants:

• Pregnancy or lactating women
• Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant
• Recipients of blood transfusion within 7 days prior to study blood draw
• Recipients of anti-microbial therapy within 14 days prior to study blood draw
• Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancer

Inclusion criteria

for Cancer Arm Participants:

• Confirmed diagnosis or highly suspicious cases of hepatobiliary malignancies
• No prior or ongoing anti-cancer therapy (local or systematic) prior to study blood draw

Exclusion criteria

for Cancer Arm Participants:

• Current diagnosis of other malignancies or multiple primary tumors
• Diagnosis of benign diseases by histopathological assessments
• Inability to characterize whether the lesion is malignant or benign
• Prior or ongoing treatment of cancer

Inclusion criteria

for Benign Diseases Arm Participants:

• Confirmed diagnosis of benign diseases of the hepatobiliary system
• No prior radical treatment of the benign diseases prior to study blood draw

Exclusion criteria

for Benign Diseases Arm Participants:

• Current or history of malignancies or precancerous lesions
• No confirmed diagnosis or inability to characterize a benign disease