Assessment of Dried Blood Spot Thyroglobulin and Urinary Iodine Concentration in Pregnant Women

To avoid iodine deficiency and its consequences in pregnant women and their offspring, women should reach a sufficient iodine intake long before conception. To monitor iodine status, median urinary iodine concentration (UIC) is widely used in pregnant women (PW). Thyroglobulin (Tg) us another marker used to assess iodine status . In this study, urine samples as well as dried blood spots will be collected to measure UIC and Tg (as well as other hormones to define thyroid function) in PW. The results shall be used to reassess the threshold which defines iodine status in PW according to UIC.

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Key information

Conditions

Iodine Deficiency Pregnancy Related

Age range

18 year–44 year

Sex eligibility

Female

Study type

Observational

Primary location

University of Otago

Dunedin, Otago, 9054, New Zealand

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Generally healthy
No major medical illness, no thyroid disease, and taking no chronic medication
No use of iodine containing dietary supplements
No use of iodine-containing X-ray /CT contrast agent or iodine containing medication within the last year
Aged between 18 and 44 at enrollment
Singleton pregnancy
Non-smoking
Residence at study site since 12 months or longer

Treatment and study plan

No intervention

Other

this is a completely observational study, NO INTERVENTION

Primary outcomes

Urinary iodine concentration and Thyroglobulin concentration in pregnant women.

Time frame: June 2018

Analysis of urine and blood samples to find urinary iodine concentration and Thyroglobulin concentration of each participant.

Sponsors and collaborators

Lead sponsor

Swiss Federal Institute of Technology

Other

Registry information

Official study title

Assessment of Dried Blood Spot Thyroglobulin in Pregnant Women to Redefine the Range of Median Urinary Iodine Concentration That Indicates Adequate Iodine Intake

Acronym: STRIPE

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Jun 5, 2017
Registry last updated: May 13, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed