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NCT Number: NCT07131072

Assessment of Diaphragmatic Mobility in Dyspneic Patients With Different Types of Interstitial Lung Diseases

dyspnea and impaired exercise capacity in IPF patients can be related, at least in part, to respiratory muscle dysfunction, in particular to diaphragm functionality. Both B-mode and M-mode ultrasound techniques have been employed to assess diaphragm excursion, which measures the distance that the diaphragm is able to move during the respiratory cycle.

recent study using lung ultrasound in assessment of diaphragmatic mobility in IPF patients and found that Diaphragmatic mobility is lower in IPF patients than in healthy controls, especially during deep inspiration. The correlation between reduced FVC and diaphragmatic excursion values in IPF patients can be of interest, since it could represent an index of functional respiratory affection performed by chest ultrasound

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain Shams university

Cairo, Egypt

About this study

Interstitial lung diseases are known to be associated with limitations in daily activities and impaired quality of life. One of the most troublesome burdens for ILD patients is dyspnea during exercise, which extends to the resting state as the disease advances. The causes of dyspnea are suggested to be a progressive decline in total lung capacity (TLC) and vital capacity, along with impairment of diffusion capacity and subsequent development of (primarily hypoxic) respiratory failure along with respiratory muscle dysfunction.

Studies have supported the advantage of ultrasonography in the assessment of diaphragmatic mobility by two-dimensional (BD) or M-mode. Others reported the investigation methods, the criteria for normal and pathological diaphragmatic function, and the perspectives of development in adult patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients presented to Ain Shams University Hospital outpatient clinic by ILD due to any cause

Exclusion criteria

  • Pregnant females
  • Patients with end stage organ failure e.g.: Renal failure, liver cell failure
  • Patients with malignancy elsewhere.
  • The patients who refuse to be entitled in the study.

Treatment and study plan

daiphragm mobility by ultrsound

Other

fibrosis score, alveolitis score by CT Chest

Other names: warricks score

spirometry ,DLCo

Other

FEV1, FVC, FEV1/FVC, DLCo

Primary outcomes

  1. diaphragm mobility assessment in different types of interstitial lung diseases

    Time frame: 1 year

    measurement of diaphragmatic excursion in cm in different types of interstitial lung diseases

Secondary outcomes

  1. Correlation between diaphragmatic mobility and functional assessment in different ILD types

    Time frame: 1 year

    find the correlation between excursion measurements and spirometry indices, DLCO and CT fibrosis score

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

A Prospective Study- Assessment of Diaphragmatic Role in Dyspneic Patients With Different Types of Interstitial Lung Disease

Important dates

Study start
2021
Primary completion
2022
Study completion
2025
First posted
Aug 20, 2025
Registry last updated
Aug 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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