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NCT Number: NCT06933030

Assessment of Customized 3D Zirconium Versus Titanium Mesh for Anterior Maxillary Ridge Augmentation With Delayed Implant Placement

The aim of the present study is to assess the customized 3D zirconium versus titanium mesh for anterior maxillary ridge augmentation with delayed implant placement.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Tanta university

Tanta, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inclusion criteria:
  • Patients from both genders with the age range of 18-60 years with good systemic health, no contraindication for periodontal surgery and able to maintain good oral hygiene.
  • Patient with anterior maxillary alveolar ridge deficiency (horizontal, vertical or combined defects) less than 2 mm in width or less than 6 mm in height - measured from the alveolar crest to the basal bone in order to be enrolled in this study. (56)
  • Adequate zone of keratinized gingiva at minimum 3mms.
  • Patient with sufficient inter-arch space for future dental rehabilitation.
  • Subjects who are not on any medication known to interfere with periodontal tissue health or healing within 6 months of the study.

Exclusion criteria

Exclusion criteria

  • History of systemic diseases (i.e. diabetes, autoimmune dysfunction, prolonged cortisone therapy, or chemotherapy) that would contraindicate periodontal surgical treatment or affect bone turn over.
  • Patients with deleterious habits like the use of tobacco chewing or smoking ones.
  • History of previous periodontal surgical treatment of the involved sites.
  • Presence of malocclusion and pathologic movement of teeth in involved sites.
  • Patient not willing to give consent for the study and poor plaque control.(57)
  • Pregnant or nursing mothers.
  • Patients with acute odontogenic infection.

Treatment and study plan

titanium mesh with bone graft with delayed implant placement.

Device

titanium mesh with bone graft with delayed implant placement.

zirconium mesh with bone graft with delayed implant placement.

Device

zirconium mesh with bone graft with delayed implant placement.

Primary outcomes

  1. clinical evaluation

    Time frame: 6 months

    The patients will be followed up clinically postoperatively every 48-72 hours for the first week then after 2weeks then one month and then after 3 months then after 6 months for preserving: Presence/absence of mesh instability, flap dehiscence, exposed mesh, bone graft loss outside the flap, hematoma or laceration.

Secondary outcomes

  1. radiographic bone volume

    Time frame: 6,12 months

    A CBCT will be done preoperatively (base line) and after 6 months and finally after 12 months postoperatively to assess dimensions of newly formed bone and its density.

  2. histologically

    Time frame: 6 months

    The bone cores, left inside the trephine burs will be carefully rinsed with a cold 5% glucose solution. The specimens will be fixed in 10% formalin solution at pH 7.2 for a week and dehydrated with a graded series of alcohols. After the pre-infiltration treatment the bone cores will then be completely embedded in 100% resin until the specimens became transparent. Finally, the bone cores will be oriented and polymerized.

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Apr 17, 2025
Registry last updated
Apr 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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