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Completed

NCT Number: NCT01850693

Assessment of Coronary Artery Disease in Stroke Patients

This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Coronary Disease Heart Diseases Myocardial Ischemia Nervous System Diseases Stroke Vascular Diseases

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 436-707, South Korea

About this study

Stroke and coronary artery disease (CAD) share common risk factors and pathological mechanisms. CAD is an important cause of death in patients with stroke.

Currently, coronary CT angiography (CCTA) is very useful non-invasive tool for detection of CAD and plaque analysis.

Therefore, the investigators aimed to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of CAD in stroke patients through follow-up (more than 5 years) using CCTA.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acute stroke patients who diagnosed by clinical and brain MR imaging
  • Who performed coronary CT angiography within 3 months after acute stroke

Exclusion criteria

  • intracranial hemorrhage including intracerebral, subdural or subarachnoid hemorrhage
  • brain tumor
  • Previous myocardial infarction
  • Previously performed percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG) or other cardiac surgery
  • Insufficient medical record
  • Poor image quality of CCTA scan

Treatment and study plan

Primary outcomes

  1. MACE (Major Adverse Cardiac Event)

    Time frame: Participants will be followed until June. 2015, an expeded average of 5 years

    MACE was included as follows: 1) all-cause mortality, 2) myocardial infarction, 3) unstable angina requiring hospitalization

Secondary outcomes

  1. Any cardiac events

    Time frame: Participants will be followed until June. 2015, an expeded average of 5 years

    • late revascularization: who underwent revascularization therapy mroe than 90days after CCTA and referral due ot new symptoms or an abnormal function test, 2) heart failure required hospitalization.

Other outcomes

  1. Repeated stroke

    Time frame: Participants will be followed until June. 2015, an expeded average of 5 years

    newly developed stroke after CCTA scan

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Collaborators

  • National Research Foundation of Korea

Registry information

Official study title

Prevalence and Characteristics of Coronary Atherosclerosis in Stroke Patients Using Coronary CT Angiography

Acronym: ACADIS

Important dates

Study start
2006
Primary completion
2012
Study completion
2015
First posted
May 9, 2013
Registry last updated
Nov 10, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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