Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion

The are 2 principal goals in this study:

1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states. 2. To measure plasma copeptin concentrations in patients with chronic renal failure under the same conditions described above, in order to characterize the impact of renal function on circulating copeptin levels in correlation to plasma AVP and urine osmolality.

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Key information

Conditions

Hypoosmolality Diabetes Insipidus Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hyperosmolality Kidney Diseases Male Urogenital Diseases Pituitary Diseases Renal Failure Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinic of Internal Medicine, Hospital Center

Biel/Bienne, 2501, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

chronic renal failure grade I through IV
healthy age-matched controls

Exclusion criteria

chronic renal failure grade V
heart failure
liver disease
nephrotic syndrome
anemia (hemoglobin level < 100 g/L)
uncontrolled hypertension (systolic BP > 160 mmHg; diastolic BP > 95 mm Hg)
coexisting severe disease
known thyroid disease
known hypocortisolism
known hypercortisolism
known diabetes insipidus
pregnancy
lactation

Sponsors and collaborators

Lead sponsor

Hospital Centre Biel/Bienne

Other

Collaborators

Brahms AG

Registry information

Important dates

Study start: 2008
Primary completion: 2009
Study completion: 2009
First posted: Jun 12, 2008
Registry last updated: Feb 27, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed