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NCT Number: NCT04344119

Assessment of Chilbains Occuring During Covid-19 Infection

Some patients infected by covid-19 develop skin manifestations. These manifestations are still not well known and there pathophysiology remain unclear. Among them, acral manifestation resembling to chilblains appears frequent and quite specific. The aim of this project is to better characterize the cutaneous manifestations occurring during Covid-19 infection with a special focus on chilblains. These acral manifestation could be due to a direct viral effect, but also to microthrombosis or vascularitis. Understanding the pathomechanisms involved could provide interesting clue for understanding not only the skin manifestations but also some of the other systemic symptoms associated to covid-19 infection. This study plan to characterize these acral manifestations by analyzing the clinical and dermoscopic patterns and to correlate them with the non-invasive vascular explorations but also immune and coagulopathy explorations that are done in the CHU of Nice in covid-19 patients.

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Key information

Conditions

Skin Manifestations COVID Chilblains Cold Injury Frostbite Pathological Conditions, Signs and Symptoms Signs and Symptoms Wounds and Injuries

Age range

Up to 90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nice

Nice, 06200, France

Location status: Recruiting

Location contact

Thierry PASSERON

CONTACT

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients with proven covid infection (using PCR, serum antibody or lung TDM) and presenting at least one cutaneous lesions that occurred during the infection.

Treatment and study plan

Primary outcomes

  1. Clinical skin manifestations

    Time frame: 3 months

    Type and description of the skin manifestations with a special focus on patients with chilblains

Secondary outcomes

  1. Histology and biological data

    Time frame: 3 months

    Data on Histology (HE staining and immunofluorescence) and on biology (blood cells counts, CRP and immune profile) will be collected in covid patient with skin manifestation

  2. Non invasive vascular examination

    Time frame: 3 months

    Vascular examination will be performed by Capillaroscopy, laser-doppler or lung TDM if clinically required

Study contacts

Contact information is provided by the study sponsor or research team.

Cynthia CAILLON

CONTACT

[email protected]

+33492034011

Sylvie MALERBA

CONTACT

[email protected]

+33492034011

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Assessment of Skin Manifestations Occuring During Covid-19 Infection With a Special Focus on Chilbains

Acronym: ChilblainCOVID

Important dates

Study start
2020
Primary completion
2021
Study completion
2027
First posted
Apr 14, 2020
Registry last updated
Jun 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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