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NCT Number: NCT05258006

Assessment of Autogenous Dentin Graft in Treatment of Infra-bony Defect

The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.

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Key information

Conditions

Periodontitis (Stage 3) Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

16 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

October 6 University

Cairo, Egypt

About this study

In this study, the investigators tested the effect of demineralized autogenous dentine as a bone graft in treatment of stage III periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and bone gain in defect sites.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with good systemic health and no contraindication for periodontal surgery.
  • Patients who are able to maintain good oral hygiene.
  • Gingival thickness for the site selected should be ≥1mm.
  • Probing depth of ≥ 6mm.
  • Patient has at least one hopeless teeth

Exclusion criteria

  • Active infectious diseases (hepatitis, tubercu¬losis, HIV, etc….).
  • Medically compromised patients.
  • Smokers and alcoholic abusers
  • People who suffer from any systemic disease that affect the periodontium.
  • Pregnant, postmenopausal women.
  • People who take anti-inflammatory drugs, anti¬biotics or vitamins within the previous 3 month.
  • People who use mouth washes regularly
  • Participants in other clinical trials.

Treatment and study plan

Autogenous demineralized dentin nanoparticles

Procedure

Effect of Autogenous demineralized dentin nanoparticles in bone gain in infrabony defect

Primary outcomes

  1. Vertical bone loss

    Time frame: 6 months

    vertical bone loss was measured from cementoenamel junction (CEJ) to the base of the bone defect in each site in group I & II.

  2. Clinical attachment level

    Time frame: 6 months

    Clinical attachment level was measured at baseline and 6 months

  3. Probing pocket depth

    Time frame: 6 months

    Probing pocket depth was measured at baseline and 6 months

  4. Bone gain

    Time frame: 6 months

    The bone gain is calculated by:

    • Preoperative VBL (at baseline): measured as the distance from cementoenamel junction (CEJ) to the base of the bone defect.
    • Postoperative VBL (after 6 months) measured as the distance from cementoenamel junction (CEJ) to the base of the bone formation.
    • Postoperative bone fill (bone gain after 6 months) [measured by subtracting the preoperative VBL from the postoperative VBL].

Secondary outcomes

  1. Plaque Index

    Time frame: 6 months

    plaque index was measured at baseline, 3, 6 months

  2. Gingival index

    Time frame: 6 months

    Gingival index was measured at baseline, 3, 6 months

Sponsors and collaborators

Lead sponsor

October 6 University

Other

Registry information

Official study title

Clinical and Radiographic Assessment of Autogenous Dentin Nanoparticles in Treatment of Stage III Periodontitis: A Split-Mouth Clinical Study

Important dates

Study start
2021
Primary completion
2021
Study completion
2022
First posted
Feb 25, 2022
Registry last updated
Feb 25, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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