Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

This research involves assessment of cognitive outcome in childhood cancer as well as evaluation of a cognitive rehabilitation program for improving learning and problem solving difficulties in children with cancer.

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Key information

Conditions

Neoplasms Adenocarcinoma Carcinoma Hematologic Diseases Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Leukemia Leukemia, Lymphoid Lymphatic Diseases Lymphoproliferative Disorders Neoplasms by Histologic Type Neoplasms, Glandular and Epithelial Precursor Cell Lymphoblastic Leukemia-Lymphoma

Age range

9 year–16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University School of Medicine

Stanford, California, 94305, United States

About this study

The purpose of this study is to help determine specific cognitive-behavioral and neurobiologic impairments associated with chemotherapy treatments in children with cancer and to assess the efficacy of a cognitive intervention program for improving cognitive impairments in these children.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

INCLUSION

Everyone:

At least 9 years of age and less than 17 years

Patients

Diagnosis of brain tumor or acute lymphocytic leukemia (ALL)
Completed all anti-cancer treatment(s) including chemotherapy, radiation and/or surgery

Control group

Typical for age

EXCLUSION

Everyone:

Non-English speaking (translated cognitive testing and MRI assessments unavailable)
MRI contraindication, including but not limited to orthodontia, metal implants, and/or pacemaker
Major sensory deficit disorders, including but not limited to blindness or deafness

Patients

Shunt placement
Received bone marrow transplant
History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes) NOT related to cancer
Participation in any concurrent cognitive rehabilitation study

Control group

History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes)

Treatment and study plan

Primary outcomes

Performance on neuropsychological testing and brain activation patterns measured by functional MRI

Time frame: 8 weeks

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Important dates

Study start: 2007
Primary completion: 2012
Study completion: 2012
First posted: Jun 22, 2007
Registry last updated: May 21, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed