Assessing the Efficacy of Image-guided Laser-assisted Enstilar® Delivery for Treatment of Psoriatic Nails

Inclusion criteria

• Informed consent obtained before any trial-related activities.
• At least 18 years of age (inclusive)
• Confirmed diagnosis of psoriatic disease with signs of nail psoriasis on at least 2 digits
• Minimum nail involvement as assessed by treating physician (N-NAIL score of ≥ 2 for at least two individual nails)

Exclusion criteria

• Insufficient knowledge of written and spoken Danish.
• Pregnant and lactating women and women who intend to become pregnant during the trial
• Pre-existing clinical manifestations of long-term side effects of corticosteroid use including but not limited to skin atrophy or telangiectasias on fingers
• Presence of any skin condition or coloration (marked suntan, hyperpigmentation, smoking-induced staining, tattoos or body art) that would interfere with the evaluation of the clinical response in the test sites or assessment
• Any non-psoriatic disease activity within test areas
• Significant history or current evidence of chronic infectious disease, systemic disorders, or organ dysfunction where the use of Enstilar is contraindicated.
• Known predisposition for hypertrophic scar formation.
• Known allergy to any of the components of Enstilar®.
• Current treatment with systemically or locally acting medications which might counter or influence the trial aim
• Received any drug as part of a research trial within 30 days prior to initial trial dosing.
• Artificial nail enhancement or damages associated with it, including (semi-) permanent nail polish e.g. acrylic based gels.
• Ongoing fungal infections of psoriatic nails
• Close affiliation with the investigator (e.g. a close relative) or persons working at the respective trial site or the participant is an employee of the sponsor
• In the opinion of the investigator, the participant is unlikely to comply with the Clinical Trial Protocol (e.g. alcoholism, drug dependency or psychotic state).