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Completed

NCT Number: NCT02410980

Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies

The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.

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Key information

Conditions

Collagen Fibril Alteration

Age range

45 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

Beckman Laser Institute Medical Clinic

Irvine, California, 92612, United States

About this study

The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques.

  • Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany)
  • Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female 45 years of age or older - Skin type scale I to III

Exclusion criteria

  • Large amount of dark, coarse hair on the arms
  • History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex
  • Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study.
  • History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma.
  • History of diabetes
  • Currently pregnant or nursing

Treatment and study plan

Tretinoin cream 0.1%

Drug

Assessment of the skin change

Primary outcomes

  1. Skin Collagen/Elastin ratio over time - Change from baseline in sun exposed, and non sun exposed skin areas.

    Time frame: up to 2 months

    The effects of tretinoin cream on human skin will be measured.

Sponsors and collaborators

Lead sponsor

University of California, Irvine

Other

Collaborators

  • Beckman Laser Institute University of California Irvine
  • Unilever R&D

Registry information

Official study title

In-vivo Non-invasive Skin Imaging Pilot Study to Assess the Effects of Tretinoin Cream Using Multi-photon Microscopy and Multi-spectral Imaging

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Apr 8, 2015
Registry last updated
Nov 1, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.