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NCT Number: NCT07191288

Assessing the Acute Effects of Virtual Reality Interventions on Stress

A Four-Arm RCT, testing the acute effects of a Virtual Reality (VR)- based slow-paced breathing intervention on subjective and physiological markers of stress. The investigator hypothesize that combining slow breathing with immersive, mystical-type VR elements will result in the greatest stress reduction.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Basel, Division of Cognitive Neuroscience

Basel, Canton of Basel-City, 4055, Switzerland

Location status: Recruiting

Location contact

Dominique de Quervain, Prof. MD

CONTACT

[email protected]

+41 61 207 02 37

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • > 60 points on the PSQ-30 out of a maximum 120-point scale in the screening
  • Healthy
  • Aged between 18-35
  • Fluent in German

Exclusion criteria

  • A current diagnosis of psychiatric disorders (self-reported)
  • Chronic medication use (except oral contraceptives)
  • Parallel participation in another medical or psychological study
  • Suicidal tendencies (PHQ-9 item 9 > 0)3
  • PHQ-9 score ≥ 10
  • A visual impairment not corrected by glasses or contact lenses

Treatment and study plan

VR (VR-Breathing+Mystical)

Device

The VR-based slow-paced breathing application is designed to provide rewarding biofeedback for a specific breathing pattern characterized by prolonged exhales. As users extend their exhales, a veil of fog gradually lifts, introducing a mystical type experience. Over time, users are rewarded with a full 360-degree panoramic view of the beautiful nature scene, accompanied by relaxing music. After approximately 5 minutes of prolonged exhales, the nature scene responds to the user's breathing by slowing down, with falling snowflakes moving more slowly, further enhancing the mystical atmosphere. This intervention was designed to be visually captivating, mystically evocative, and emotionally engaging. Duration: 10 minutes.

VR (VR-Mystical)

Device

Users will experience the gradual unveiling of a beautiful natural landscape as the fog lifts, and eventually, the scene slows down similar to the VR Breathing+Mystical condition. However, this application does not provide any biofeedback or breathing instructions. Users are invited to passively observe the unfolding experience, immersing themselves in the environment for 10 minutes. Relaxing music accompanies the scene. This condition relies solely on the immersive and aesthetic qualities of the virtual environment to potentially induce relaxation.

Computer (Non-VR-Breathing)

Device

In this conventional breathing intervention, participants will be instructed to follow a slow-paced breathing pattern guided by a simple visual cue (an expanding and contracting circle) displayed on a computer screen for 10 minutes. This condition is designed to guide slow-paced breathing without incorporating any rewarding elements.

VR (VR-Control)

Drug

In the control condition, participants will watch a neutral documentary for 10 minutes in VR. This condition is used to control for the effects of the immersive VR experience. It does not include any components related to guided breathing or mystical-type content, or any form of rewarding elements.

Primary outcomes

  1. Subjective stress

    Time frame: Assessed before and after the 10-minute interventions.

    Subjective stress measured using visual analogue scales (VAS) on a computer

Secondary outcomes

  1. Mood

    Time frame: Assessed before and after the 10-minute interventions.

    Mood measured using visual analogue scales (VAS) on a computer.

  2. Anxiety

    Time frame: Assessed before and after the 10-minute interventions.

    Anxiety measured using visual analogue scales (VAS) on a computer.

  3. Relaxation

    Time frame: Assessed before and after the 10-minute interventions.

    Relaxation measured using visual analogue scales (VAS) on a computer.

  4. Electrodermal Activity

    Time frame: Assessed during the 10-minute interventions.

    Physiological responses measured via Electrodermal Activity.

  5. Respiration

    Time frame: Assessed during the 10-minute interventions.

    Physiological responses measured via Piezoelectric Sensor (detecting variations in abdominal movement during respiration).

  6. Blood volume pulse

    Time frame: Assessed during the 10-minute interventions.

    Blood volume pulse measured via Photoplethysmography.

  7. Heart rate (variability)

    Time frame: Assessed during the 10-minute interventions.

    Heart rate outcomes (e.g., HR, HRV) measured via Electrocardiogram.

  8. Perceived mysticality

    Time frame: Assessed after the 10-minute interventions.

    Perceived mysticality assessed using the Mystical Experience Questionnaire-30 questionnaire.

  9. User experience

    Time frame: Assessed after the 10-minute interventions.

    Average user experience measured via visual analogue scales (VAS) on a computer.

Study contacts

Contact information is provided by the study sponsor or research team.

Fabian Mueller, Msc

CONTACT

[email protected]

+41612070272

Sponsors and collaborators

Lead sponsor

Prof. Dominique de Quervain, MD

Other

Registry information

Official study title

Assessing the Acute Effects of Virtual Reality Interventions on Stress: A Four-Arm RCT

Acronym: VR_Stress_25

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 24, 2025
Registry last updated
Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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