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Completed

NCT Number: NCT06055335

Assessing Lung Dynamics and Respiratory Functions in Minimal Flow Anesthesia: A Prospective Study

The patients were randomized into two groups medium flow anesthesia (MeFA) and minimal flow anesthesia (MiFA). While MeFA received medium flow anesthesia with 2 lt/min, MiFA received minimal flow anesthesia with 0.5 lt/min fresh gas flow. In both groups dynamic compliance values, peak inspiratory pressure (PIP) values, total inhalation anesthetic drug consumption, total remifentanil drug consumption, duration of anesthesia, and duration of surgery were recorded. The FVC, FEV1, and FEV1/FVC values of the patients in both groups were evaluated and noted 24 hours before the operation, after the operation 2nd, 8th, and 24th hours.

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Key information

Conditions

Medium Flow Anesthesia Behavior Compliance, Patient Health Behavior Minimal Flow Anesthesia Patient Acceptance of Health Care Patient Compliance Peak Inspiratuar Pressure Pulmonary Function Test Treatment Adherence and Compliance

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Erkan Cem ÇELİK

Erzurum, 25080, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-II
  • 18-65 years of age, who will undergo elective laparoscopic cholecystectomy surgery

Exclusion criteria

  • ASA III-IV
  • Smokers
  • Body mass index (BMI) > 40 kg / m2,
  • Patients with cardiovascular system disease
  • Chronic respiratory diseases,
  • Patients whose pulmonary function tests cannot be applied and who have problems with pulmonary function tests during the examination of the chest disease consultant

Treatment and study plan

Medium flow anesthesia

Other

Group MeFA; after reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane with remifentanil infusion, medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane. The vaporizer was closed at the end of the last suture, and the flow was increased to 80% oxygen at 6 lt/min.

Minimal flow anesthesia

Other

Group MiFA; after reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane with remifentanil infusion, minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane. The vaporizer was closed at the end of the last suture, and the flow was increased to 80% oxygen at 6 lt/min.

Primary outcomes

  1. Dynamic Compliance assessment

    Time frame: 5th minutes after endotracheal intubation

    Dynamic Compliance will be assessed 5th minutes after endotracheal intubation

  2. Dynamic Compliance assessment

    Time frame: 5th minutes after surgical incision

    Dynamic Compliance will be assessed 5th minutes after the surgical incision

  3. Dynamic Compliance assessment

    Time frame: 10th minutes after surgical incision

    Dynamic Compliance will be assessed 10th minutes after the surgical incision

  4. Dynamic Compliance assessment

    Time frame: 30th minutes after surgical incision

    Dynamic Compliance will be assessed 30th minutes after the surgical incision

  5. Dynamic Compliance assessment

    Time frame: 60th minutes after surgical incision

    Dynamic Compliance will be assessed 60th minutes after the surgical incision

  6. Dynamic Compliance assessment

    Time frame: immediately after the end of the surgical suturing

    Dynamic Compliance will be assessed immediately after the end of the surgical suturing

  7. Peak inspiratory pressure assessment

    Time frame: 5th minutes after endotracheal intubation

    Peak inspiratory pressure will be assessed 5th minutes after endotracheal intubation

  8. Peak inspiratory pressure assessment

    Time frame: 5th minutes after the surgical incision

    Peak inspiratory pressure will be assessed 5th minutes after the surgical incision

  9. Peak inspiratory pressure assessment

    Time frame: 10th minutes after the surgical incision

    Peak inspiratory pressure will be assessed 10th minutes after the surgical incision

  10. Peak inspiratory pressure assessment

    Time frame: 30th minutes after the surgical incision

    Peak inspiratory pressure will be assessed 30th minutes after the surgical incision

  11. Peak inspiratory pressure assessment

    Time frame: 60th minutes after the surgical incision

    Peak inspiratory pressure will be assessed 60th minutes after the surgical incision

  12. Peak inspiratory pressure assessment

    Time frame: immediately after the end of the surgical suturing

    Peak inspiratory pressure will be assessed immediately after the end of the surgical suturing

Secondary outcomes

  1. FEV1 measures assessment

    Time frame: 24 hours before the operation

    FEV1 measures assessment will be assessed 24 hours before the operation

  2. FEV1 measures assessment

    Time frame: 2nd hour after the operation

    FEV1 measures assessment will be assessed 2nd hours after the operation

  3. FEV1 measures assessmentt

    Time frame: 8th hour after the operation

    FEV1 measures assessment will be assessed 8th hours after the operation

  4. FEV1 measures assessment

    Time frame: 24th hour after the operation

    FEV1 measures assessment will be assessed 24th hours after the operation

  5. FVC measures assessment

    Time frame: 24 hours before the operation

    FVC measures assessment will be assessed 24 hours before the operation

  6. FVC measures assessment

    Time frame: 2nd hour after the operation

    FVC measures assessment will be assessed 2nd hour after the operation

  7. FVC measures assessment

    Time frame: 8th hour after the operation

    FVC measures assessment will be assessed 8th hour after the operation

  8. FVC measures assessment

    Time frame: 24th hour after the operation

    FVC measures assessment will be assessed 24th hours after the operation

  9. FEV1/FVC measures assessment

    Time frame: 24 hours before the operation

    FEV1/FVC measures assessment will be assessed 24 hours before the operation

  10. FEV1/FVC measures assessment

    Time frame: 2nd hour after the operation

    FEV1/FVC measures assessment will be assessed 2nd hour after the operation

  11. FEV1/FVC measures assessment

    Time frame: 8th hour after the operation

    FEV1/FVC measures assessment will be assessed 8th hour after the operation

  12. FEV1/FVC measures assessment

    Time frame: 24th hour after the operation

    FEV1/FVC measures assessment will be assessed 24th hour after the operation

Sponsors and collaborators

Lead sponsor

Ataturk University

Other

Registry information

Official study title

EVALUATION OF LUNG DYNAMICS AND RESPIRATORY FUNCTIONS IN PATIENTS APPLIED WITH MINIMAL FLOW ANESTHESIA: A PROSPECTIVE, RANDOMIZED STUDY

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Sep 26, 2023
Registry last updated
Sep 26, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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