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NCT Number: NCT04443439

Assess the Risk of Cerebrovascular Disease

Intracranial artery stenosis is an important cause of ischemic stroke, but the degree of intracranial artery stenosis is not completely matched with the symptoms of ischemic stroke. Asymptomatic carotid stenosis (ACS) refers to does not appear related neurological symptoms of carotid stenosis and stroke or transient ischemic attack of carotid stenosis, did not happen cerebrovascular events such as stroke, but there have been a different degree of cognitive impairment, be badly in need of development of noninvasive imaging methods, objective evaluation of the ACS group cognitive impairment, and predict the ACS risk of ischemic stroke. Therefore, this topic proposed comprehensive cognitive assessment, CTA, double modal MRI techniques, clinical and biochemical indicator detection, mathematical modeling and statistical analysis techniques, assess the ACS group and normal person the cognitive ability, the difference of NVC and local perfusion, and follow-up ACS crowd of ischemic stroke and other cardiovascular events, discuss ACS and cognitive impairment, the correlation of NVC and local perfusion abnormalities, screening of radiographic predictor of ischemic stroke, and in the follow-up of ACS population in testing the sensitivity of the series of indicators and specific degrees.

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Mild stenosis group: CTA suggested carotid stenosis < 30%;
  • Moderate stenosis group: CTA suggested carotid stenosis of 30-69%;
  • Severe stenosis group: CTA indicated carotid stenosis ≥70%;

Exclusion criteria

  • dementia, MMSE score < 21;
  • previous carotid stenosis related neurological symptoms or transient ischemic attack;
  • other craniocerebral lesions, such as craniocerebral trauma, tumor, inflammation, and complications of great vessels (cerebral infarction or cerebral malacia);
  • contraindications for MRI examination;
  • recent use of psychoactive drugs or hormones.

Treatment and study plan

GE Discovery MR750 3.0t superconducting MRI

Device

T2WI, FLAIR, DWI, 3D BRAVO, 3D-ASL, rs-fMRI, DKI sequences to exclude other organic lesions

Primary outcomes

  1. Dynamic change and correlation analysis of multi-dimensional features of ACS degree and cognitive impairment

    Time frame: 2020.01

    The Montreal cognitive assessment (MoCA) scale was used to evaluate the differences in cognitive function between ACS and the healthy control group in different dimensions, and the horizontal correlation analysis between ACS and cognitive impairment was conducted according to the dimensions of cognitive impairment and the degree of ACS.

Study contacts

Contact information is provided by the study sponsor or research team.

Wen Wang, Ph.D.

CONTACT

[email protected]

+8618629066628 ext. +8618629066628

Sponsors and collaborators

Lead sponsor

Tang-Du Hospital

Other

Registry information

Official study title

Head and Neck CTA Combined With Multimodal MRI to Assess the Risk of Cerebrovascular Disease

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Jun 23, 2020
Registry last updated
Oct 25, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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