Assess Itch Behavior in Nickel Sulphate Sensitized Volunteers

Inclusion criteria

• Subjects ≥18 years old.
• Subjects with a history of diagnosis of sensitization to Nickel sulphate.
• Delayed type hypersensitivity demonstrated by positive reaction with epicutaneous or patch test.
• Skin Phototype II-III.
• Women with fertile age and a negative result in the pregnancy test before inclusion. Women must use an adequate contraceptive method during the study.
• Written informed consent prior to inclusion.
• Able and willing to comply with protocol procedures and to follow the investigator's instructions.

Criteria for treatment initiation: At day 7, before starting treatment, subjects must meet the inclusion criteria and all the following criteria: ≥ 3 VAS and eczema intensity of (+ +) or (+++) according to ICDRG scale.

Exclusion criteria

• Active cutaneous disease causing itch (active eczema, urticaria or insect bites)
• Active systemic disease that may induce itch (hepatic or renal disease).
• Active psychiatric disease that could interfere with symptom assessment.
• Treatment with drugs inducing itch.
• Treatment with oral or topical preparations that could interfere with the itching sensation induced by patch test.
• Treatment with systemic or topical corticosteroids, antihistaminics or calcineurin inhibitors.
• Active skin disease in the back that may interfere with the assessment of response to topical application of allergen
• Pregnancy or lactation
• Subjects with contraindications specified in Summary of Product Characteristics (SPC).