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Completed

NCT Number: NCT06627972

Asprosin Level in Individuals With Periodontal Disease

The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis and periodontitis.

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Key information

Conditions

Periodontitis Gingival Diseases Gingivitis Infections Mouth Diseases Periodontal Diseases Periodontal Health Stomatognathic Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Adiyaman University, Faculty of Dentistry

Adıyaman, Turkey (Türkiye)

About this study

This study is investigating the level of asprosin hormone in gingival crevicular fluid of patients with periodontal diseases such as gingivitis and periodontitis, and observing the healthy patient in terms of the hormone levels, as well. 75 volunteer patients aged 18-45 years old were included in this study. These patients were divided equally to three groups: Group I; periodontal health, Group II; gingivitis, Group III; periodontitis.The body fluids including serum, saliva and gingival crevicular fluid were collected from this participants according to the proper protocol and their storage was provided under certain conditions. ELISA tests for asprosin and Tumour necrosis factor alpha were made in laboratory. Also, clinical measurements such as plaque index, bleeding on probing, probing pocket depth were recorded at first visit day of the participants. The data were analysed according to the different periodontal conditions, and correlated with asprosin hormone and tumour necrosis factor alpha level in gingival crevicular fluid, serum and saliva.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Exclusion criteria

  • Those with any systemic disease
  • Individuals who take medication regularly
  • Pregnant or lactating women
  • Individuals with menopause and anthropause
  • Those who have undergone any periodontal treatment in the last six months
  • Smokers

Treatment and study plan

Primary outcomes

  1. Asprosin level

    Time frame: Day 1

    Asprosin level (ng/mL) in gingival crevicular fluid, serum and saliva.

Secondary outcomes

  1. TNF-alpha levels

    Time frame: Day 1

    TNF-alpha level (pg/mL) in gingival crevicular fluid, serum and saliva

  2. Plaque index

    Time frame: Day 1

    The index was recorded from all participants as numerical between 0-3

  3. bleeding on probing

    Time frame: Day 1

    The bleeding on probing is stated by percentage. the ratio of the number of sites with bleeding gingiva on probing around teeth to total surfaces of all examined teeth

  4. probing pocket depth

    Time frame: Day 1

    The parameters were recorded as mm in all participant. The probing pocket depth is measured from the marginal gingiva to bottom of pocket using a periodontal probe, from six surfaces of each tooth.

  5. body mass index

    Time frame: Day 1

    the weight and height is combined to report BMI in kg/m2

Sponsors and collaborators

Lead sponsor

Mustafa Kemal University

Other

Registry information

Official study title

IS THERE A RELATIONSHIP BETWEEN PERIODONTAL CONDITION AND ASPROSIN LEVEL IN GINGIVAL CREVICULAR FLUID?

Acronym: ALIGCF

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Oct 4, 2024
Registry last updated
Oct 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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